SpiceCom: A database of phytochemicals in major spices

Turmeric

Overview
Compounds
Activities
References
Crop: Turmeric
Total No. of activities: 67
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1
Benammi H, El Hiba O, Romane A, Gamrani H.(2014). A blunted anxiolytic like effect of curcumin against acute lead induced anxiety in rat: involvement of serotonin.. Acta histochemica. 116(5):920-5. DOI: 10.1016/j.acthis.2014.03.002
  • Anxiolytic : Curcumin
2
Chen G, Li J, Cai Y, Zhan J, Gao J, Song M, Shi Y, Yang Z(2017). A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy. Scientific Reports. 7:44210. DOI: 10.1038/srep44210
  • Anti-hepatocellular carcinoma : Curcumin
3
Ullah R, Rehman A, Zafeer MF, Rehman L, Khan YA, Khan MA, Khan SN, Khan AU, Abidi SM.(2017). Anthelmintic Potential of Thymoquinone and Curcumin on Fasciola gigantica.. PloS one. 12(2). DOI: 10.1371/journal.pone.0171267
  • Anthelmintic : Curcumin
4
Park SI, Lee EH, Kim SR, Jang YP(2017). Anti‐apoptotic effects of Curcuma longa L. extract and its curcuminoids against blue light‐induced cytotoxicity in A2E‐laden human retinal pigment epithelial cells. Journal of Pharmacy and Pharmacology. 69(3):334-340. DOI: 10.1111/jphp.12691
  • Anti-AMD : Demethoxycurcumin
  • Cytoprotective : Bisdemethoxycurcumin
  • Cytoprotective : Curcumin
  • Cytoprotective : Demethoxycurcumin
  • Cytotoxic : Curcumin
5
Akinyemi AJ, Oboh G, Oyeleye SI, Ogunsuyi O(2017). Anti-amnestic Effect of Curcumin in Combination with Donepezil, an Anticholinesterase Drug: Involvement of Cholinergic System. Neurotoxicity Research. 31(4):560-569. DOI: 10.1007/s12640-017-9701-5
  • Anti-amnestic : Curcumin
6
Shakeri A, Ward N, Panahi Y, Sahebkar A.(2018). Anti-angiogenic activity of curcumin in cancer therapy: a narrative review.. Current vascular pharmacology. 16. DOI: 10.2174/1570161116666180209113014
  • Angiogenic : Curcumin
7
Jin M, Park SY, Shen Q, Lai Y, Ou X, Mao Z, Lin D, Yu Y, Zhang W(2018). Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells. International Journal of Molecular Medicine. 41(1):521-530. DOI: 10.3892/ijmm.2017.3217
  • Anti-neuroinflammatory : Curcumin
8
Wang XP, Wang QX, Lin HP, Chang N(2017). Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma. Food & Function. 8(9):3319-3326. DOI: 10.1039/c7fo00555e
  • Antiproliferative : Curcumin
  • Antitumor : Curcumin
9
A.J. Ruby, G. Kuttan, K. Dinesh Babu, K.N. Rajasekharan, R. Kuttan(1995). Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters. 94(1): 79-83. DOI: 10.1016/0304-3835(95)03827-J
  • Antioxidant : Curcumin
  • Antitumor : Curcumin
10
Li X, Ma S, Yang P, Sun B, Zhang Y, Sun Y, Hao M, Mou R, Jia Y(2018). Anticancer effects of curcumin on nude mice bearing lung cancer A549 cell subsets SP and NSP cells.. Oncology letters. 16(5):6756-6762. DOI: 10.3892/ol.2018.9488
  • Anti-lung cancer : Curcumin
11
Chen C, Long L, Zhang F, Chen Q, Chen C, Yu X, Liu Q, Bao J, Long Z(2018). Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum. PLoS One. 13(3). DOI: 10.1371/journal.pone.0194284
  • Antifungal : Beta-elemene
  • Antifungal : Curcumenol
  • Antifungal : Curcumin
  • Antifungal : Curcumol
  • Antifungal : Curdione
  • Antifungal : Curzerene
  • Antifungal : Germacrone
  • Antifungal : Isocurcumenol
12
Mohamed M. Radwan, Nurhayat Tabanca, David E. Wedge ,Amer H,Tarawneh, Stephen J. Cutler (2014). Antifungal compounds from turmeric and nutmeg with activity against plant pathogens. Fitoterapia. 99:341-346. DOI: 10.1016/j.fitote.2014.08.021
  • Antifungal : Demethoxycurcumin
13
Alaikov T, Konstantinov SM, Tzanova T, Dinev K, Topashka-Ancheva M, Berger MR.(2007). Antineoplastic and anticlastogenic properties of curcumin.. Annals of the New York Academy of Sciences. 1095:355-70. DOI: 10.1196/annals.1397.039
  • Anticlastogen : Curcumin
14
Liu YM, Zhang QZ, Xu DH, Fu YW, Lin DJ, Zhou SY, Li JP(2017). Antiparasitic efficacy of curcumin from Curcuma longa against Ichthyophthirius multifiliis in grass carp. Veterinary Parasitology. 236:128-136. DOI: 10.1016/j.vetpar.2017.02.011
  • Antiparasitic : Curcumin
15
Busari ZA, Dauda KA1, Morenikeji OA, Afolayan F, Oyeyemi OT, Meena J, Sahu D, Panda AK(2017). Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles. Frontiers in Pharmacology. 8:622. DOI: 10.3389/fphar.2017.00622
  • Antimalarial : Curcumin
  • Antiplasmodial : Curcumin
16
Mehta K, Pantazis P, McQueen T, Aggarwal BB.(1997). Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines.. Anti-cancer drugs. 8(5):470-81. DOI: 10.1097/00001813-199706000-00010
  • Antiproliferative : Curcumin
17
Chen M, Chang YY, Huang S, Xiao LH, Zhou W, Zhang LY, Li C, Zhou RP, Tang J, Lin L, Du ZY, Zhang K(2017). Aromatic‐Turmerone Attenuates LPS‐Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4‐Dependent Signaling Pathway. Molecular Nutrition & Food Research. 62(2). DOI: 10.1002/mnfr.201700281
  • Anti-neuroinflammatory : Ar-turmerone
18
Alves TF, Chaud MV, Grotto D, Jozala AF, Pandit R, Rai M, Dos Santos CA(2018). Association of Silver Nanoparticles and Curcumin Solid Dispersion: Antimicrobial and Antioxidant Properties. AAPS PharmSciTech. 19(1):225-231. DOI: 10.1208/s12249-017-0832-z
  • Antimicrobial : Curcumin
  • Antioxidant : Curcumin
19
Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S(2017). Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling. Cellular Physiology and Biochemistry. 41(2):661-677. DOI: 10.1159/000457945
  • Antiapoptotic : Curcumin
  • Antiosteoporotic : Curcumin
  • Cytoprotective : Curcumin
20
Enomoto A, Yamada J, Morita A, Miyagawa K(2017). Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 815:1-5. DOI: 10.1016/j.mrgentox.2016.12.005
  • Apoptosis inducer : Bisdemethoxycurcumin
21
Tyagi AK, Prasad S, Majeed M, Aggarwal BB(2017). Calebin A, a novel component of turmeric, suppresses NF-κB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization. Phytomedicine. 34:171-181. DOI: 10.1016/j.phymed.2017.08.021
  • Antiproliferative : Calebin a
  • Apoptosis inducer : Calebin a
22
Kalaycıoğlu Z, Gazioğlu I, Erim FB.(2017). Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.. Natural product research. 31(24):31. DOI: 10.1080/14786419.2017.1299727
  • Anticholinesterase : Bisdemethoxycurcumin
  • Anticholinesterase : Demethoxycurcumin
  • Antidiabetic : Bisdemethoxycurcumin
  • Antidiabetic : Curcumin
  • Antidiabetic : Demethoxycurcumin
  • Antioxidant : Curcumin
23
Curic S, Wu Y, Shan B, Schaaf C, Utpadel D, Lange M, Kuhlen D, Perone MJ, Arzt E, Stalla GK, Renner U.(2013). Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas.. Journal of neuro-oncology. 113(3):385-96. DOI: 10.1007/s11060-013-1148-9
  • Antitumorigenic : Curcumin
24
Akinyemi AJ, Oboh G, Fadaka AO, Olatunji BP, Akomolafe S(2017). Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. NeuroToxicology. 62:75-79. DOI: 10.1016/j.neuro.2017.05.004
  • Antiacetylcholinesterase : Curcumin
25
Choi GY, Kim HB, Hwang ES, Lee S, Kim MJ, Choi JY, Lee SO, Kim SS, Park JH(2017). Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats. Mediators of Inflammation. 2017:6280925. DOI: 10.1155/2017/6280925
  • Antidepressant : Curcumin
  • Antiinflammatory : Curcumin
  • Neuroprotective : Curcumin
26
Han S, Xu J, Guo X, Huang M(2017). Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production. Clinical and Experimental Pharmacology and Physiology. 45(1):84-93. DOI: 10.1111/1440-1681.12848
  • Anti-influenza A : Curcumin
27
Du ZY1, Bao YD, Liu Z, Qiao W, Ma L, Huang ZS, Gu LQ, Chan AS(2006). Curcumin analogs as potent aldose reductase inhibitors. Archiv der Pharmazie. 339(3):123-8. DOI: 10.1002/ardp.200500205
  • Aldose-Reductase-Inhibitor : Curcumin
28
Lee HY, Kim SW, Lee GH, Choi MK, Chung HW, Lee YC, Kim HR, Kwon HJ, Chae H(2017). Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress. Scientific Letters. 7(1):6513. DOI: 10.1038/s41598-017-06872-y
  • Hepatoprotective : Curcumin
29
Messner DJ, Robinson T, Kowdley KV(2017). Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro. Nutrition and Cancer. 69(3):481-489. DOI: 10.1080/01635581.2017.1274407
  • Antitumor-Promoter : Curcumin
30
Loganes C, Lega S, Bramuzzo M, Vecchi Brumatti L, Piscianz E, Valencic E, Tommasini A, Marcuzzi A(2017). Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage. Nutrients. 9(6):E578. DOI: 10.3390/nu9060578
  • Antiapoptotic : Curcumin
31
Li B, Hu Y, Zhao Y, Cheng M, Qin H, Cheng T, Wang Q, Peng X, Zhang X(2017). Curcumin Attenuates Titanium Particle-Induced Inflammation by Regulating Macrophage Polarization In Vitro and In Vivo. Frontiers in Immunology. 8:55. DOI: 10.3389/fimmu.2017.00055
  • Anti-osteolysis : Curcumin
32
Cheng T, Zhao Y, Li B, Cheng M, Wang J, Zhang X(2017). Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model. Mediators of Inflammation. 2017:5784374. DOI: 10.1155/2017/5784374
  • Anti-osteolysis : Curcumin
33
Chang M, Wu M, Li H(2017). Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN/PI3K/AKT signalling pathway. American Journal of Translational Research. 9(12):5567–5575. DOI: NoDOI3
  • Anti-hepatocellular carcinoma : Curcumin
34
Wang X, Deng J, Yuan J, Tang X, Wang Y, Chen H, Liu Y, Zhou L(2017). Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells. International Journal of Oncology. 51(2):467-477. DOI: 10.3892/ijo.2017.4037
  • Antiglioma : Curcumin
  • Antiproliferative : Curcumin
  • Antitumor : Curcumin
35
Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK(2008). Curcumin has Anticonvulsant Activity onIncreasing Current Electroshock Seizuresin Mice. Phytotherapy research. 22(12):1660-1664. DOI: 10.1002/ptr.2551
  • Anticonvulsant : Curcumin
  • Anxiogenic : Curcumin
36
Pan Y, Zhao D, Yu N, An T, Miao J, Mo F, Gu Y, Zhang D, Gao S, Jiang G(2017). Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes. Royal Society open science. 4(11):170917. DOI: 10.1098/rsos.170917
  • Antiobesity : Curcumin
37
Mou S, Zhou Z, He Y, Liu F, Gong L(2017). Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a. Oncology Letters. 14(4):4937-4942. DOI: 10.3892/ol.2017.6739
  • Anti-laryngeal cancer : Curcumin
  • Antiproliferative : Curcumin
  • Apoptosis inducer : Curcumin
38
Wang Z, Zhang K, Zhu Y, Wang D, Shao Y, Zhang J(2017). Curcumin inhibits hypoxia-induced proliferation and invasion of MG-63 osteosarcoma cells via downregulating Notch1. Molecular Medicine Reports. 15(4):1747-1752. DOI: 10.3892/mmr.2017.6159
  • Antiinvasive : Curcumin
  • Antiproliferative : Curcumin
39
Anoop K.SinghGurmel S.SidhuT.DeepaRadha K.Maheshwari(1996). Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell. Cancer Letters. 107(1):109-115. DOI: 10.1016/0304-3835(96)04357-1
  • Anticancer : Curcumin
40
Taverna S, Fontana S, Monteleone F, Pucci M, Saieva L, De Caro V, Cardinale VG, Giallombardo M, Vicario E, Rolfo C, Leo GD, Alessandro R(2016). Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via exosomal miR-21. Oncotarget. 7(21):30420-39. DOI: 10.18632/oncotarget.8483
  • Antiangiogenic : Curcumin
  • Antiangiogenic : Curcumin
41
Ortega-Domínguez B, Aparicio-Trejo OE, García-Arroyo FE, León-Contreras JC3, Tapia E2, Molina-Jijón E1, Hernández-Pando R, Sánchez-Lozada LG, Barrera-Oviedo D, Pedraza-Chaverri J(2017). Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic. Food and Chemical Toxicology. 107(Part A):373-385. DOI: 10.1016/j.fct.2017.07.018
  • Renoprotective : Curcumin
42
Cai‐Jun Xie, Ai‐Ping Gu, Jun Cai, Yi Wu, and Rui‐Cong Chen(2018). Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke. Brain and Behaviour. 8(2). DOI: 10.1002/brb3.921
  • Anti-apoptotic : Curcumin
  • Neuroprotective : Curcumin
43
Wang J, Liu Y, Li XH1, Zeng XC, Li J5, Zhou J, Xiao B, Hu K(2017). Curcumin protects neuronal cells against status-epilepticus-induced hippocampal damage through induction of autophagy and inhibition of necroptosis. Login Register Shibboleth Mobile Cart Advanced Search Canadian Journal of Physiology and Pharmacology. 95(5):501-509. DOI: 10.1139/cjpp-2016-0154
  • Neuroprotective : Curcumin
44
Zhou QM, Sun Y, Lu YY, Zhang H, Chen QL, Su SB(2017). Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis. Cancer Cell International. 17:84. DOI: 10.1186/s12935-017-0453-3
  • Anti-breast cancer : Curcumin
45
Zhao Q, Guan J, Qin Y, Ren P, Zhang Z, Lv J, Sun S, Zhang C, Mao W(2018). Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. Biomedicine & Pharmacotherapy. 97:115-119. DOI: 10.1016/j.biopha.2017.09.078
  • Antitumor : Curcumin
46
Zhao W, Zhou X, Qi G, Guo Y(2018). Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation. Journal of Biochemical and Molecular Toxicology. 32(5). DOI: 10.1002/jbt.22049
  • Anti-prostate cancer : Curcumin
47
Xu S, Jiang B, Wang H, Shen C, Chen H, Zeng L(2017). Curcumin Suppresses Intestinal Fibrosis by Inhibition of PPARγ-Mediated Epithelial-Mesenchymal Transition. Evidence-Based Complementary and Alternative Medicine. 2017:7876064. DOI: 10.1155/2017/7876064
  • Antifibrogenic : Curcumin
48
Lee YH, Song NY, Suh J, Kim DH, Kim W, Ann J, Lee J, Baek JH, Na HK, Surh YJ(2018). Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. Cancer Letters. 431:219-229. DOI: 10.1016/j.canlet.2018.05.036
  • Anti-colon cancer : Curcumin
49
Zhu X, Zhu R(2018). Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway. OncoTargets and Therapy. 11:3521-3531. DOI: 10.2147/OTT.S159236
  • Anti-laryngeal cancer : Curcumin
  • Antiproliferative : Curcumin
50
Marini E, Di Giulio M, Magi G, Di Lodovico S, Cimarelli ME, Brenciani A, Nostro A, Cellini L, Facinelli B(2018). Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus. Phytotherapy Research. 32(3):488-495. DOI: 10.1002/ptr.5994
  • Antibiofilm : Curcumin
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