SpiceCom: A database of phytochemicals in major spices

Turmeric

Overview
Compounds
Activities
References
Crop: Turmeric
Total No. of activities: 67
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1
A.J. Ruby, G. Kuttan, K. Dinesh Babu, K.N. Rajasekharan, R. Kuttan(1995). Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters. 94(1): 79-83. DOI: 10.1016/0304-3835(95)03827-J
  • Antioxidant : Curcumin
  • Antitumor : Curcumin
2
Abbaoui A, Chatoui H, El Hiba O, Gamrani H(2017). Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson’s disease. Neuroscience Letters. 660:103-108. DOI: 10.1016/j.neulet.2017.09.032
  • Neuroprotective : Curcumin
3
Akinyemi AJ, Oboh G, Fadaka AO, Olatunji BP, Akomolafe S(2017). Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. NeuroToxicology. 62:75-79. DOI: 10.1016/j.neuro.2017.05.004
  • Antiacetylcholinesterase : Curcumin
4
Akinyemi AJ, Oboh G, Ogunsuyi O, Abolaji AO, Udofia A(2018). Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model. Metabolic Brain Disease. 33(2):369-375. DOI: 10.1007/s11011-017-0100-7
  • Antiacetylcholinesterase : Curcumin
  • Antiaging : Curcumin
5
Akinyemi AJ, Oboh G, Oyeleye SI, Ogunsuyi O(2017). Anti-amnestic Effect of Curcumin in Combination with Donepezil, an Anticholinesterase Drug: Involvement of Cholinergic System. Neurotoxicity Research. 31(4):560-569. DOI: 10.1007/s12640-017-9701-5
  • Anti-amnestic : Curcumin
6
Alaikov T, Konstantinov SM, Tzanova T, Dinev K, Topashka-Ancheva M, Berger MR.(2007). Antineoplastic and anticlastogenic properties of curcumin.. Annals of the New York Academy of Sciences. 1095:355-70. DOI: 10.1196/annals.1397.039
  • Anticlastogen : Curcumin
7
Ali AH, Sudi S, Basir R, Embi N, Sidek HM(2017). The Antimalarial Effect of Curcumin Is Mediated by the Inhibition of Glycogen Synthase Kinase-3β. Journal of Medicinal Food. 20(2):152-161. DOI: 10.1089/jmf.2016.3813
  • Antimalarial : Curcumin
8
Alves TF, Chaud MV, Grotto D, Jozala AF, Pandit R, Rai M, Dos Santos CA(2018). Association of Silver Nanoparticles and Curcumin Solid Dispersion: Antimicrobial and Antioxidant Properties. AAPS PharmSciTech. 19(1):225-231. DOI: 10.1208/s12249-017-0832-z
  • Antimicrobial : Curcumin
  • Antioxidant : Curcumin
9
Anoop K.SinghGurmel S.SidhuT.DeepaRadha K.Maheshwari(1996). Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell. Cancer Letters. 107(1):109-115. DOI: 10.1016/0304-3835(96)04357-1
  • Anticancer : Curcumin
10
Araújo LA, Araújo RG, Gomes FO, Lemes SR, Almeida LM, Maia LJ, Gonçalves PJ, Mrué F, Silva-Junior NJ, Melo-Reis PR(2016). Physicochemical/photophysical characterization and angiogenic properties of Curcuma longa essential oil. Anais da Academia Brasileira de Ciencias. 88(3):1889-1897. DOI: 10.1590/0001-3765201620150600
  • Angiogenic : Curcumin
11
Babu PS, Srinivasan K.(1997). Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats.. Molecular and cellular biochemistry. 166(2-Jan):169-75. DOI: 10.1023/A:1006819605211
  • Hypolipidemic : Curcumin
12
Benammi H, El Hiba O, Romane A, Gamrani H.(2014). A blunted anxiolytic like effect of curcumin against acute lead induced anxiety in rat: involvement of serotonin.. Acta histochemica. 116(5):920-5. DOI: 10.1016/j.acthis.2014.03.002
  • Anxiolytic : Curcumin
13
Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK(2008). Curcumin has Anticonvulsant Activity onIncreasing Current Electroshock Seizuresin Mice. Phytotherapy research. 22(12):1660-1664. DOI: 10.1002/ptr.2551
  • Anticonvulsant : Curcumin
  • Anxiogenic : Curcumin
14
Busari ZA, Dauda KA1, Morenikeji OA, Afolayan F, Oyeyemi OT, Meena J, Sahu D, Panda AK(2017). Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles. Frontiers in Pharmacology. 8:622. DOI: 10.3389/fphar.2017.00622
  • Antimalarial : Curcumin
  • Antiplasmodial : Curcumin
15
Cai‐Jun Xie, Ai‐Ping Gu, Jun Cai, Yi Wu, and Rui‐Cong Chen(2018). Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke. Brain and Behaviour. 8(2). DOI: 10.1002/brb3.921
  • Anti-apoptotic : Curcumin
  • Neuroprotective : Curcumin
16
Ceremuga TE, Helmrick K, Kufahl Z, Kelley J, Keller B, Philippe F, Golder J, Padrón G.(2017). Investigation of the Anxiolytic and Antidepressant Effects of Curcumin, a Compound From Turmeric (Curcuma longa), in the Adult Male Sprague-Dawley Rat.. Holistic nursing practice. 31(3):193-203. DOI: 10.1097/HNP.0000000000000208
  • Antidepressant : Curcumin
  • Anxiolytic : Curcumin
17
Chang M, Wu M, Li H(2017). Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN/PI3K/AKT signalling pathway. American Journal of Translational Research. 9(12):5567–5575. DOI: NoDOI3
  • Anti-hepatocellular carcinoma : Curcumin
18
Chen C, Jin S, Xiang X, Wang X, Shi Q, Yang M, Ji S, Huang R, Song C(2017). Enrichment and Cytotoxic Activity of Curcuminoids from Turmeric Using Macroporous Resins. Journal of Food Science. 82(9):2024-2030. DOI: 10.1111/1750-3841.13800
  • Cytotoxic : Bisdemethoxycurcumin
  • Cytotoxic : Curcumin
  • Cytotoxic : Demethoxycurcumin
19
Chen C, Long L, Zhang F, Chen Q, Chen C, Yu X, Liu Q, Bao J, Long Z(2018). Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum. PLoS One. 13(3). DOI: 10.1371/journal.pone.0194284
  • Antifungal : Beta-elemene
  • Antifungal : Curcumenol
  • Antifungal : Curcumin
  • Antifungal : Curcumol
  • Antifungal : Curdione
  • Antifungal : Curzerene
  • Antifungal : Germacrone
  • Antifungal : Isocurcumenol
20
Chen G, Li J, Cai Y, Zhan J, Gao J, Song M, Shi Y, Yang Z(2017). A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy. Scientific Reports. 7:44210. DOI: 10.1038/srep44210
  • Anti-hepatocellular carcinoma : Curcumin
21
Chen M, Chang YY, Huang S, Xiao LH, Zhou W, Zhang LY, Li C, Zhou RP, Tang J, Lin L, Du ZY, Zhang K(2017). Aromatic‐Turmerone Attenuates LPS‐Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4‐Dependent Signaling Pathway. Molecular Nutrition & Food Research. 62(2). DOI: 10.1002/mnfr.201700281
  • Anti-neuroinflammatory : Ar-turmerone
22
Cheng T, Zhao Y, Li B, Cheng M, Wang J, Zhang X(2017). Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model. Mediators of Inflammation. 2017:5784374. DOI: 10.1155/2017/5784374
  • Anti-osteolysis : Curcumin
23
Choi GY, Kim HB, Hwang ES, Lee S, Kim MJ, Choi JY, Lee SO, Kim SS, Park JH(2017). Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats. Mediators of Inflammation. 2017:6280925. DOI: 10.1155/2017/6280925
  • Antidepressant : Curcumin
  • Antiinflammatory : Curcumin
  • Neuroprotective : Curcumin
24
Curic S, Wu Y, Shan B, Schaaf C, Utpadel D, Lange M, Kuhlen D, Perone MJ, Arzt E, Stalla GK, Renner U.(2013). Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas.. Journal of neuro-oncology. 113(3):385-96. DOI: 10.1007/s11060-013-1148-9
  • Antitumorigenic : Curcumin
25
Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S(2017). Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling. Cellular Physiology and Biochemistry. 41(2):661-677. DOI: 10.1159/000457945
  • Antiapoptotic : Curcumin
  • Antiosteoporotic : Curcumin
  • Cytoprotective : Curcumin
26
Darbinyan LV, Hambardzumyan LE, Simonyan KV, Chavushyan VA, Manukyan LP, Badalyan SA, Khalaji N, Sarkisian VH(2017). Protective effects of curcumin against rotenone-induced rat model of Parkinson’s disease: in vivo electrophysiological and behavioral study. Metabolic Brain Disease. 32(6):1791–1803. DOI: 10.1007/s11011-017-0060-y
  • Neuroprotective : Curcumin
27
Du ZY1, Bao YD, Liu Z, Qiao W, Ma L, Huang ZS, Gu LQ, Chan AS(2006). Curcumin analogs as potent aldose reductase inhibitors. Archiv der Pharmazie. 339(3):123-8. DOI: 10.1002/ardp.200500205
  • Aldose-Reductase-Inhibitor : Curcumin
28
Enomoto A, Yamada J, Morita A, Miyagawa K(2017). Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 815:1-5. DOI: 10.1016/j.mrgentox.2016.12.005
  • Apoptosis inducer : Bisdemethoxycurcumin
29
Fan Y, Chen H, Peng H, Huang F, Zhong J, Zhou J(2017). Molecular Mechanisms of Curcumin Renoprotection in Experimental Acute Renal Injury. Frontiers in pharmacology. 8:912. DOI: 10.3389/fphar.2017.00912
  • Nephroprotective : Curcumin
30
Frank A, Abu-Lafi S, Adawi A, Schwed JS, Stark H, Rayan A(2017). From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation.. Inflammation research :. 66(10):923-929. DOI: 10.1007/s00011-017-1075-x
  • Antiinflammatory : Bisdemethoxycurcumin
  • Antiinflammatory : Bisdemethoxycurcumin
31
Galli GM, Da Silva AS, Biazus AH, Reis JH, Boiago MM, Topazio JP, Migliorini MJ, Guarda NS, Moresco RN, Ourique AF, Santos CG, Lopes LS, Baldissera MD, Stefani LM(2018). Feed addition of curcumin to laying hens showed anticoccidial effect, and improved egg quality and animal health. Research in Veterinary Science. 118:101-106. DOI: 10.1016/j.rvsc.2018.01.022
  • Anticoccidial : Curcumin
32
Garrido-Armas M, Corona JC, Escobar ML, Torres L, Ordóñez-Romero F, Hernández-Hernández A, Arenas-Huertero F(2018). Paraptosis in human glioblastoma cell line induced by curcumin. Toxicology in Vitro. 51:63-73. DOI: 10.1016/j.tiv.2018.04.014
  • paraptosis-inducer : Curcumin
33
Han S, Xu J, Guo X, Huang M(2017). Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production. Clinical and Experimental Pharmacology and Physiology. 45(1):84-93. DOI: 10.1111/1440-1681.12848
  • Anti-influenza A : Curcumin
34
Huang HI, Chio CC, Lin JY(2018). Inhibition of EV71 by curcumin in intestinal epithelial cells. PloS one. 13(1). DOI: 10.1371/journal.pone.0191617
  • Anti-EV71 : Curcumin
  • Antiviral : Curcumin
35
Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z(2018). Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation. Journal of Molecular Neuroscience : MN. 64(1):129-139. DOI: 10.1007/s12031-017-1006-x
  • Neuroprotective : Curcumin
36
Huang L, Li A, Liao G, Yang F, Yang J, Chen X, Jiang X(2017). Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA. Oncology Letters. 14(1):1080-1088. DOI: 10.3892/ol.2017.6273
  • Anti-breast cancer : Curcumol
  • Apoptosis inducer : Curcumol
37
Jain A, Rani V(2018). Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts. Molecular and Cellular Biochemistry. 442(1-2):81-96. DOI: 10.1007/s11010-017-3195-6
  • Cardioprotective : Curcumin
38
Jin M, Park SY, Shen Q, Lai Y, Ou X, Mao Z, Lin D, Yu Y, Zhang W(2018). Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells. International Journal of Molecular Medicine. 41(1):521-530. DOI: 10.3892/ijmm.2017.3217
  • Anti-neuroinflammatory : Curcumin
39
Kádasi A, Maruniaková N, Štochmaľová A, Bauer M, Grossmann R, Harrath AH, Kolesárová A, Sirotkin AV(2017). Direct effect of curcumin on porcine ovarian cell functions. Animal Reproduction Science. 182:77-83. DOI: 10.3892/ijo.2017.403710.1016/j.anireprosci.2017.05.001
  • Anti-gonadal : Curcumin
40
Kádasi A, Maruniaková N, Štochmaľová A, Bauer M, Grossmann R, Harrath AH, Kolesárová A, Sirotkin AV(2017). Direct effect of curcumin on porcine ovarian cell functions. Animal Reproduction Science. 182:77-83. DOI: 10.1016/j.anireprosci.2017.05.001
  • Anti-gonadal : Curcumin
41
Kalaycıoğlu Z, Gazioğlu I, Erim FB.(2017). Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.. Natural product research. 31(24):31. DOI: 10.1080/14786419.2017.1299727
  • Anticholinesterase : Bisdemethoxycurcumin
  • Anticholinesterase : Demethoxycurcumin
  • Antidiabetic : Bisdemethoxycurcumin
  • Antidiabetic : Curcumin
  • Antidiabetic : Demethoxycurcumin
  • Antioxidant : Curcumin
42
Khatri DK, Juvekar AR(2016). Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson's disease.. Pharmacology, biochemistry, and behavior. 150-151:39-47. DOI: 10.1016/j.pbb.2016.09.002
  • Neuroprotective : Curcumin
43
Khuwaja G, Khan MM, Ishrat T, Ahmad A, Raza SS, Ashafaq M, Javed H, Khan MB, Khan A, Vaibhav K, Safhi MM, Islam F(2011). Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. Brain research. 1368:254-63. DOI: 10.1016/j.brainres.2010.10.023
  • Antioxidant : Curcumin
  • Neuroprotective : Curcumin
44
Kim K, Kim JJ, Jung Y, Noh JY, Syed AS, Kim CY, Lee MY, Lim KM4, Bae ON, Chung JH(2017). Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric). Journal of Natural Products. 80(1):196-200. DOI: 10.1021/acs.jnatprod.6b00331
  • Antivasoconstrictive : Cyclocurcumin
45
Kim M, Kim Y(2010). Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet.. Nutrition research and practice. 4(3):191-5. DOI: 10.4162/nrp.2010.4.3.191
  • Hypocholesterolemic : Curcumin
46
Kukula-Koch W, Grabarska A, Łuszczki J, Czernicka L, Nowosadzka E, Gumbarewicz E, Jarząb A, Audo G, Upadhyay S, Głowniak K, Stepulak A(2018). Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography. Phytotherapy Research. 32(5):933-942. DOI: 10.1002/ptr.6035
  • Anti-lung cancer : Bisdemethoxycurcumin
  • Anti-lung cancer : Demethoxycurcumin
  • Antiproliferative : Bisdemethoxycurcumin
  • Antiproliferative : Demethoxycurcumin
47
Lee GH, Lee HY, Choi MK, Chung HW, Kim SW, Chae HJ(2016). Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress. BMC Research Notes. 10(1):77. DOI: 10.1186/s13104-017-2409-z
  • Antioxidant : Curcumin
  • Hepatoprotective : Curcumin
48
Lee HY, Kim SW, Lee GH, Choi MK, Chung HW, Lee YC, Kim HR, Kwon HJ, Chae H(2017). Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress. Scientific Letters. 7(1):6513. DOI: 10.1038/s41598-017-06872-y
  • Hepatoprotective : Curcumin
49
Lee YH, Song NY, Suh J, Kim DH, Kim W, Ann J, Lee J, Baek JH, Na HK, Surh YJ(2018). Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. Cancer Letters. 431:219-229. DOI: 10.1016/j.canlet.2018.05.036
  • Anti-colon cancer : Curcumin
50
Li B, Hu Y, Zhao Y, Cheng M, Qin H, Cheng T, Wang Q, Peng X, Zhang X(2017). Curcumin Attenuates Titanium Particle-Induced Inflammation by Regulating Macrophage Polarization In Vitro and In Vivo. Frontiers in Immunology. 8:55. DOI: 10.3389/fimmu.2017.00055
  • Anti-osteolysis : Curcumin
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