SpiceCom: A database of phytochemicals in major spices

Turmeric

Overview
Compounds
Activities
References
Crop: Turmeric
Total No. of activities: 67
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1
Akinyemi AJ, Oboh G, Ogunsuyi O, Abolaji AO, Udofia A(2018). Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model. Metabolic Brain Disease. 33(2):369-375. DOI: 10.1007/s11011-017-0100-7
  • Antiacetylcholinesterase : Curcumin
  • Antiaging : Curcumin
2
Alves TF, Chaud MV, Grotto D, Jozala AF, Pandit R, Rai M, Dos Santos CA(2018). Association of Silver Nanoparticles and Curcumin Solid Dispersion: Antimicrobial and Antioxidant Properties. AAPS PharmSciTech. 19(1):225-231. DOI: 10.1208/s12249-017-0832-z
  • Antimicrobial : Curcumin
  • Antioxidant : Curcumin
3
Cai‐Jun Xie, Ai‐Ping Gu, Jun Cai, Yi Wu, and Rui‐Cong Chen(2018). Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke. Brain and Behaviour. 8(2). DOI: 10.1002/brb3.921
  • Anti-apoptotic : Curcumin
  • Neuroprotective : Curcumin
4
Chen C, Long L, Zhang F, Chen Q, Chen C, Yu X, Liu Q, Bao J, Long Z(2018). Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum. PLoS One. 13(3). DOI: 10.1371/journal.pone.0194284
  • Antifungal : Beta-elemene
  • Antifungal : Curcumenol
  • Antifungal : Curcumin
  • Antifungal : Curcumol
  • Antifungal : Curdione
  • Antifungal : Curzerene
  • Antifungal : Germacrone
  • Antifungal : Isocurcumenol
5
Galli GM, Da Silva AS, Biazus AH, Reis JH, Boiago MM, Topazio JP, Migliorini MJ, Guarda NS, Moresco RN, Ourique AF, Santos CG, Lopes LS, Baldissera MD, Stefani LM(2018). Feed addition of curcumin to laying hens showed anticoccidial effect, and improved egg quality and animal health. Research in Veterinary Science. 118:101-106. DOI: 10.1016/j.rvsc.2018.01.022
  • Anticoccidial : Curcumin
6
Garrido-Armas M, Corona JC, Escobar ML, Torres L, Ordóñez-Romero F, Hernández-Hernández A, Arenas-Huertero F(2018). Paraptosis in human glioblastoma cell line induced by curcumin. Toxicology in Vitro. 51:63-73. DOI: 10.1016/j.tiv.2018.04.014
  • paraptosis-inducer : Curcumin
7
Huang HI, Chio CC, Lin JY(2018). Inhibition of EV71 by curcumin in intestinal epithelial cells. PloS one. 13(1). DOI: 10.1371/journal.pone.0191617
  • Anti-EV71 : Curcumin
  • Antiviral : Curcumin
8
Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z(2018). Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation. Journal of Molecular Neuroscience : MN. 64(1):129-139. DOI: 10.1007/s12031-017-1006-x
  • Neuroprotective : Curcumin
9
Jain A, Rani V(2018). Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts. Molecular and Cellular Biochemistry. 442(1-2):81-96. DOI: 10.1007/s11010-017-3195-6
  • Cardioprotective : Curcumin
10
Jin M, Park SY, Shen Q, Lai Y, Ou X, Mao Z, Lin D, Yu Y, Zhang W(2018). Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells. International Journal of Molecular Medicine. 41(1):521-530. DOI: 10.3892/ijmm.2017.3217
  • Anti-neuroinflammatory : Curcumin
11
Kukula-Koch W, Grabarska A, Łuszczki J, Czernicka L, Nowosadzka E, Gumbarewicz E, Jarząb A, Audo G, Upadhyay S, Głowniak K, Stepulak A(2018). Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography. Phytotherapy Research. 32(5):933-942. DOI: 10.1002/ptr.6035
  • Anti-lung cancer : Bisdemethoxycurcumin
  • Anti-lung cancer : Demethoxycurcumin
  • Antiproliferative : Bisdemethoxycurcumin
  • Antiproliferative : Demethoxycurcumin
12
Lee YH, Song NY, Suh J, Kim DH, Kim W, Ann J, Lee J, Baek JH, Na HK, Surh YJ(2018). Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. Cancer Letters. 431:219-229. DOI: 10.1016/j.canlet.2018.05.036
  • Anti-colon cancer : Curcumin
13
Li X, Ma S, Yang P, Sun B, Zhang Y, Sun Y, Hao M, Mou R, Jia Y(2018). Anticancer effects of curcumin on nude mice bearing lung cancer A549 cell subsets SP and NSP cells.. Oncology letters. 16(5):6756-6762. DOI: 10.3892/ol.2018.9488
  • Anti-lung cancer : Curcumin
14
Marini E, Di Giulio M, Magi G, Di Lodovico S, Cimarelli ME, Brenciani A, Nostro A, Cellini L, Facinelli B(2018). Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus. Phytotherapy Research. 32(3):488-495. DOI: 10.1002/ptr.5994
  • Antibiofilm : Curcumin
15
Perna A, De Luca A, Adelfi L, Pasquale T, Varriale B, Esposito T(2018). Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line. BMC Complementary and Alternative Medicine. 18(1):63. DOI: 10.1186/s12906-018-2125-9
  • Antiinflammatory : Curcumin
  • Antioxidant : Curcumin
  • Antiproliferative : Curcumin
16
Shakeri A, Ward N, Panahi Y, Sahebkar A.(2018). Anti-angiogenic activity of curcumin in cancer therapy: a narrative review.. Current vascular pharmacology. 16. DOI: 10.2174/1570161116666180209113014
  • Angiogenic : Curcumin
17
Wang J, Li XM, Bai Z, Chi BX, Wei Y, Chen X(2018). Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. Journal of Ethnopharmacology. 210:1-9. DOI: 10.1016/j.jep.2017.06.037
  • Anti-colon cancer : Curcumol
  • Antiproliferative : Curcumol
18
Zhao Q, Guan J, Qin Y, Ren P, Zhang Z, Lv J, Sun S, Zhang C, Mao W(2018). Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. Biomedicine & Pharmacotherapy. 97:115-119. DOI: 10.1016/j.biopha.2017.09.078
  • Antitumor : Curcumin
19
Zhao W, Zhou X, Qi G, Guo Y(2018). Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation. Journal of Biochemical and Molecular Toxicology. 32(5). DOI: 10.1002/jbt.22049
  • Anti-prostate cancer : Curcumin
20
Zhu X, Zhu R(2018). Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway. OncoTargets and Therapy. 11:3521-3531. DOI: 10.2147/OTT.S159236
  • Anti-laryngeal cancer : Curcumin
  • Antiproliferative : Curcumin
21
Abbaoui A, Chatoui H, El Hiba O, Gamrani H(2017). Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson’s disease. Neuroscience Letters. 660:103-108. DOI: 10.1016/j.neulet.2017.09.032
  • Neuroprotective : Curcumin
22
Akinyemi AJ, Oboh G, Fadaka AO, Olatunji BP, Akomolafe S(2017). Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. NeuroToxicology. 62:75-79. DOI: 10.1016/j.neuro.2017.05.004
  • Antiacetylcholinesterase : Curcumin
23
Akinyemi AJ, Oboh G, Oyeleye SI, Ogunsuyi O(2017). Anti-amnestic Effect of Curcumin in Combination with Donepezil, an Anticholinesterase Drug: Involvement of Cholinergic System. Neurotoxicity Research. 31(4):560-569. DOI: 10.1007/s12640-017-9701-5
  • Anti-amnestic : Curcumin
24
Ali AH, Sudi S, Basir R, Embi N, Sidek HM(2017). The Antimalarial Effect of Curcumin Is Mediated by the Inhibition of Glycogen Synthase Kinase-3β. Journal of Medicinal Food. 20(2):152-161. DOI: 10.1089/jmf.2016.3813
  • Antimalarial : Curcumin
25
Busari ZA, Dauda KA1, Morenikeji OA, Afolayan F, Oyeyemi OT, Meena J, Sahu D, Panda AK(2017). Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles. Frontiers in Pharmacology. 8:622. DOI: 10.3389/fphar.2017.00622
  • Antimalarial : Curcumin
  • Antiplasmodial : Curcumin
26
Ceremuga TE, Helmrick K, Kufahl Z, Kelley J, Keller B, Philippe F, Golder J, Padrón G.(2017). Investigation of the Anxiolytic and Antidepressant Effects of Curcumin, a Compound From Turmeric (Curcuma longa), in the Adult Male Sprague-Dawley Rat.. Holistic nursing practice. 31(3):193-203. DOI: 10.1097/HNP.0000000000000208
  • Antidepressant : Curcumin
  • Anxiolytic : Curcumin
27
Chang M, Wu M, Li H(2017). Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN/PI3K/AKT signalling pathway. American Journal of Translational Research. 9(12):5567–5575. DOI: NoDOI3
  • Anti-hepatocellular carcinoma : Curcumin
28
Chen C, Jin S, Xiang X, Wang X, Shi Q, Yang M, Ji S, Huang R, Song C(2017). Enrichment and Cytotoxic Activity of Curcuminoids from Turmeric Using Macroporous Resins. Journal of Food Science. 82(9):2024-2030. DOI: 10.1111/1750-3841.13800
  • Cytotoxic : Bisdemethoxycurcumin
  • Cytotoxic : Curcumin
  • Cytotoxic : Demethoxycurcumin
29
Chen G, Li J, Cai Y, Zhan J, Gao J, Song M, Shi Y, Yang Z(2017). A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy. Scientific Reports. 7:44210. DOI: 10.1038/srep44210
  • Anti-hepatocellular carcinoma : Curcumin
30
Chen M, Chang YY, Huang S, Xiao LH, Zhou W, Zhang LY, Li C, Zhou RP, Tang J, Lin L, Du ZY, Zhang K(2017). Aromatic‐Turmerone Attenuates LPS‐Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4‐Dependent Signaling Pathway. Molecular Nutrition & Food Research. 62(2). DOI: 10.1002/mnfr.201700281
  • Anti-neuroinflammatory : Ar-turmerone
31
Cheng T, Zhao Y, Li B, Cheng M, Wang J, Zhang X(2017). Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model. Mediators of Inflammation. 2017:5784374. DOI: 10.1155/2017/5784374
  • Anti-osteolysis : Curcumin
32
Choi GY, Kim HB, Hwang ES, Lee S, Kim MJ, Choi JY, Lee SO, Kim SS, Park JH(2017). Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats. Mediators of Inflammation. 2017:6280925. DOI: 10.1155/2017/6280925
  • Antidepressant : Curcumin
  • Antiinflammatory : Curcumin
  • Neuroprotective : Curcumin
33
Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S(2017). Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling. Cellular Physiology and Biochemistry. 41(2):661-677. DOI: 10.1159/000457945
  • Antiapoptotic : Curcumin
  • Antiosteoporotic : Curcumin
  • Cytoprotective : Curcumin
34
Darbinyan LV, Hambardzumyan LE, Simonyan KV, Chavushyan VA, Manukyan LP, Badalyan SA, Khalaji N, Sarkisian VH(2017). Protective effects of curcumin against rotenone-induced rat model of Parkinson’s disease: in vivo electrophysiological and behavioral study. Metabolic Brain Disease. 32(6):1791–1803. DOI: 10.1007/s11011-017-0060-y
  • Neuroprotective : Curcumin
35
Enomoto A, Yamada J, Morita A, Miyagawa K(2017). Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 815:1-5. DOI: 10.1016/j.mrgentox.2016.12.005
  • Apoptosis inducer : Bisdemethoxycurcumin
36
Fan Y, Chen H, Peng H, Huang F, Zhong J, Zhou J(2017). Molecular Mechanisms of Curcumin Renoprotection in Experimental Acute Renal Injury. Frontiers in pharmacology. 8:912. DOI: 10.3389/fphar.2017.00912
  • Nephroprotective : Curcumin
37
Frank A, Abu-Lafi S, Adawi A, Schwed JS, Stark H, Rayan A(2017). From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation.. Inflammation research :. 66(10):923-929. DOI: 10.1007/s00011-017-1075-x
  • Antiinflammatory : Bisdemethoxycurcumin
  • Antiinflammatory : Bisdemethoxycurcumin
38
Han S, Xu J, Guo X, Huang M(2017). Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production. Clinical and Experimental Pharmacology and Physiology. 45(1):84-93. DOI: 10.1111/1440-1681.12848
  • Anti-influenza A : Curcumin
39
Huang L, Li A, Liao G, Yang F, Yang J, Chen X, Jiang X(2017). Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA. Oncology Letters. 14(1):1080-1088. DOI: 10.3892/ol.2017.6273
  • Anti-breast cancer : Curcumol
  • Apoptosis inducer : Curcumol
40
Kádasi A, Maruniaková N, Štochmaľová A, Bauer M, Grossmann R, Harrath AH, Kolesárová A, Sirotkin AV(2017). Direct effect of curcumin on porcine ovarian cell functions. Animal Reproduction Science. 182:77-83. DOI: 10.3892/ijo.2017.403710.1016/j.anireprosci.2017.05.001
  • Anti-gonadal : Curcumin
41
Kádasi A, Maruniaková N, Štochmaľová A, Bauer M, Grossmann R, Harrath AH, Kolesárová A, Sirotkin AV(2017). Direct effect of curcumin on porcine ovarian cell functions. Animal Reproduction Science. 182:77-83. DOI: 10.1016/j.anireprosci.2017.05.001
  • Anti-gonadal : Curcumin
42
Kalaycıoğlu Z, Gazioğlu I, Erim FB.(2017). Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.. Natural product research. 31(24):31. DOI: 10.1080/14786419.2017.1299727
  • Anticholinesterase : Bisdemethoxycurcumin
  • Anticholinesterase : Demethoxycurcumin
  • Antidiabetic : Bisdemethoxycurcumin
  • Antidiabetic : Curcumin
  • Antidiabetic : Demethoxycurcumin
  • Antioxidant : Curcumin
43
Kim K, Kim JJ, Jung Y, Noh JY, Syed AS, Kim CY, Lee MY, Lim KM4, Bae ON, Chung JH(2017). Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric). Journal of Natural Products. 80(1):196-200. DOI: 10.1021/acs.jnatprod.6b00331
  • Antivasoconstrictive : Cyclocurcumin
44
Lee HY, Kim SW, Lee GH, Choi MK, Chung HW, Lee YC, Kim HR, Kwon HJ, Chae H(2017). Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress. Scientific Letters. 7(1):6513. DOI: 10.1038/s41598-017-06872-y
  • Hepatoprotective : Curcumin
45
Li B, Hu Y, Zhao Y, Cheng M, Qin H, Cheng T, Wang Q, Peng X, Zhang X(2017). Curcumin Attenuates Titanium Particle-Induced Inflammation by Regulating Macrophage Polarization In Vitro and In Vivo. Frontiers in Immunology. 8:55. DOI: 10.3389/fimmu.2017.00055
  • Anti-osteolysis : Curcumin
46
Liu YM, Zhang QZ, Xu DH, Fu YW, Lin DJ, Zhou SY, Li JP(2017). Antiparasitic efficacy of curcumin from Curcuma longa against Ichthyophthirius multifiliis in grass carp. Veterinary Parasitology. 236:128-136. DOI: 10.1016/j.vetpar.2017.02.011
  • Antiparasitic : Curcumin
47
Loganes C, Lega S, Bramuzzo M, Vecchi Brumatti L, Piscianz E, Valencic E, Tommasini A, Marcuzzi A(2017). Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage. Nutrients. 9(6):E578. DOI: 10.3390/nu9060578
  • Antiapoptotic : Curcumin
48
Messner DJ, Robinson T, Kowdley KV(2017). Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro. Nutrition and Cancer. 69(3):481-489. DOI: 10.1080/01635581.2017.1274407
  • Antitumor-Promoter : Curcumin
49
Messner DJ, Surrago C, Fiordalisi C, Chung WY, Kowdley KV(2017). Isolation and characterization of iron chelators from turmeric (Curcuma longa): selective metal binding by curcuminoids. BioMetals. 30(5):699-708. DOI: 10.1007/s10534-017-0038-6
  • Metal-Chelator : Curcumin
50
Mou S, Zhou Z, He Y, Liu F, Gong L(2017). Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a. Oncology Letters. 14(4):4937-4942. DOI: 10.3892/ol.2017.6739
  • Anti-laryngeal cancer : Curcumin
  • Antiproliferative : Curcumin
  • Apoptosis inducer : Curcumin
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