SpiceCom: A database of phytochemicals in major spices

Ginger

Overview
Compounds
Activities
References
Crop: Ginger
Total No. of activities: 94
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1
Joo JH, Hong SS, Cho YR, Seo DW(2016). 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncology Reports. 35(2):779-784. DOI: 10.3892/or.2015.4405
  • Antiinvasive : 10-gingerol
  • Antiproliferative : 10-gingerol
  • Antitumor : 10-gingerol
2
Chen CY, Cheng KC, Chang AY, Lin YT, Hseu YC, Wang HM(2012). 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 13(2):1762-1777. DOI: 10.3390/ijms13021762
  • Antioxidant : 10-shogaol
3
Abdel-Aziz H, Nahrstedt A, Petereit F, Windeck T, Ploch M, Verspohl EJ(2005). 5-HT3 Receptor Blocking Activity of Arylalkanes Isolated from the Rhizome of Zingiber officinale. Planta Medica. 71(7):609-616. DOI: 10.1055/s-2005-871265
  • Anti-5-HT : 10-gingerol
  • Anti-5-HT : 4-gingerol
  • Anti-5-HT : 6-dehydrogingerdione
  • Anti-5-HT : 6-gingerol
  • Anti-5-HT : 6-shogaol
  • Anti-5-HT : 8-gingerol
  • Anti-5-HT : 8-shogaol
4
Hsu YL, Chen CY, Hou MF, Tsai EM, Jong YJ, Hung CH, Kuo PL(2010). 6‐Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c‐Jun N‐terminal kinase pathways in human breast cancer cells. Molecular Nutrition & Food Research. 54(9):1307-17. DOI: 10.1002/mnfr.200900125
  • Anti-breast cancer : 6-dehydrogingerdione
  • Apoptosis inducer : 6-dehydrogingerdione
5
El-Bakly WM, Louka ML, El-Halawany AM, Schaalan MF(2012). 6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation. Cancer Chemotherapy and Pharmacology. 70(6):833-841. DOI: 10.1007/s00280-012-1975-y
  • Cardioprotective : 6-gingerol
6
Wang S, Tian M, Yang R, Jing Y, Chen W, Wang J, Zheng X, Wang F(2018). 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE−/− Mice Exposed to Chronic Mild Stress. Cardiovascular Toxicology. :11-Jan. DOI: 10.1007/s12012-018-9452-4
  • Antiatherosclerotic : 6-gingerol
7
Yang G, Wang S, Zhong L, Dong X, Zhang W, Jiang L, Geng C, Sun X, Liu X, Chen M, Ma Y(2012). 6-Gingerol Induces Apoptosis through Lysosomal‐Mitochondrial Axis in Human Hepatoma G2 Cells. Phytotherapy research. 26(11):1667-1673. DOI: 10.1002/ptr.4632
  • Apoptosis inducer : 6-gingerol
8
Wang S, Sun X, Jiang L, Liu X, Chen M, Yao X, Sun Q, Yang G(2016). 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chemico-Biological Interactions. 256:249-56. DOI: 10.1016/j.cbi.2016.07.020
  • Antiapoptotic : 6-gingerol
  • Autophagy inducer : 6-gingerol
9
Lin CB, Lin CC, Tsay GJ(2012). 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest. Evidence-Based Complementary and Alternative Medicine. 2012:326096. DOI: 10.1155/2012/326096
  • Anti-colon cancer : 6-gingerol
10
Fan J, Yang X, Bi Z(2015). 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumor Biology. 36(2):1135-1141. DOI: 10.1007/s1327
  • Anticancer : 6-gingerol
  • Apoptosis inducer : 6-gingerol
11
Pallashri Saha, Atul Katarkar, Bornita Das, Aritra Bhattacharyya & KeyaChaudhuri(2015). 6-Gingerol inhibits Vibrio cholerae-inducedproinflammatory cytokines in intestinal epithelialcells via modulation of NF-κB. Pharmaceutical Biology. 54(9). DOI: 10.3109/13880209.2015.1110598
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
12
Yang G, Zhong L, Jiang L, Geng C, Cao J, Sun X, Liu X, Chen M, Ma Y(2011). 6-Gingerol Prevents Patulin‐induced Genotoxicity in HepG2 Cells. Phytotherapy Research. 25(10):1480-1485. DOI: 10.1002/ptr.3446
  • Chemoprotective : 6-gingerol
13
Kim HS, Lee SH, Byun Y, Park HD(2015). 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Scientific reports. 5:8656. DOI: 10.1038/srep08656
  • Antibiofilm : 6-gingerol
14
Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh, Fang-Rong Chang(2017). 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. International Journl of Molecular Sciences. 18(1). DOI: 10.3390/ijms18010168
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-shogaol
  • Antiobesity : 6-paradol
15
Chen CY, Liu TZ, Liu YW, Tseng WC, Liu RH, Lu FJ, Lin YS, Kuo SH, Chen CH(2007). 6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an Oxidative Stress-Mediated Caspase-Dependent Mechanism. Journal of Agricultural and Food Chemistry. 55(3):948-954. DOI: 10.1021/jf0624594
  • Apoptosis inducer : 6-shogaol
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