SpiceCom: A database of phytochemicals in major spices

Ginger

Overview
Compounds
Activities
References
Crop: Ginger
Total No. of activities: 94
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1
Abdel-Aziz H, Nahrstedt A, Petereit F, Windeck T, Ploch M, Verspohl EJ(2005). 5-HT3 Receptor Blocking Activity of Arylalkanes Isolated from the Rhizome of Zingiber officinale. Planta Medica. 71(7):609-616. DOI: 10.1055/s-2005-871265
  • Anti-5-HT : 10-gingerol
  • Anti-5-HT : 4-gingerol
  • Anti-5-HT : 6-dehydrogingerdione
  • Anti-5-HT : 6-gingerol
  • Anti-5-HT : 6-shogaol
  • Anti-5-HT : 8-gingerol
  • Anti-5-HT : 8-shogaol
2
Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ(2006). Mode of action of gingerols and shogaols on 5-HT3 receptors: Binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. European Journal of Pharmacology. 530(2-Jan):136-143. DOI: 10.1016/j.ejphar.2005.10.049
  • Anticholinergic : 10-gingerol
  • Anticholinergic : 6-gingerol
  • Anticholinergic : 6-shogaol
  • Anticholinergic : 8-gingerol
  • Antiemetic : 10-gingerol
  • Antiemetic : 6-gingerol
  • Antiemetic : 6-shogaol
  • Antiemetic : 8-gingerol
  • Antineurokininergic : 10-gingerol
  • Antineurokininergic : 6-gingerol
  • Antineurokininergic : 6-shogaol
  • Antineurokininergic : 8-gingerol
3
Agarwal M, Walia S, Dhingra S, Khambay BP(2001). Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes. Pest Management Science. 57(3):289-300. DOI: 10.1002/ps.263
  • Antifeedant : 6-gingerol
  • Antifungal : Dehydrozingerone
  • Insect growth regulatory : [6]-dehydroshogaol
4
Ajayi BO, Adedara IA, Farombi EO(2018). Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice. Human & Experimental Toxicology. January. DOI: 10.1177/0960327117751235
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
  • Antiulcer : 6-gingerol
  • NF-kB-Inhibitor : 6-gingerol
5
Ajayi BO, Adedara IA, Farombi EO(2015). Pharmacological Activity of 6-Gingerol in Dextran Sulphate Sodium-induced Ulcerative Colitis in BALB/c Mice. Phytotherapy research. 29(4):566-572. DOI: 10.1002/ptr.5286
  • Anticolitic : 6-gingerol
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
6
Alibakhshi T, Khodayar MJ, Khorsandi L, Rashno M, Zeidooni L(2018). Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomedicine & Pharmacotherapy. 105:225–232. DOI: 10.1016/j.biopha.2018.05.085
  • Nephroprotective : Gingerone
7
Amri M, Touil-Boukoffa C(2016). In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol. Asian Pacific Journal of Tropical Medicine. 9(8):749-756. DOI: 10.1016/j.apjtm.2016.06.013
  • Antihydatic : 6-gingerol
  • Cytotoxic : 6-gingerol
  • Immunomodulatory : 6-gingerol
  • Larvicidal : 6-gingerol
8
Annamalai G, Kathiresan S, Kannappan N(2016). [6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells. Biomedicine & Pharmacotherapy. 82:226-236. DOI: 10.1016/j.biopha.2016.04.044
  • Anti-laryngeal cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Cytotoxic : 6-shogaol
9
Annamalai G, Suresh K(2018). [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis. Biomedicine & Pharmacotherapy. 98:484-490. DOI: 10.1016/j.biopha.2017.12.009
  • Antiinflammatory : 6-shogaol
  • Antitumorigenic : 6-shogaol
  • NF-kB-Inhibitor : 6-shogaol
10
Bernard M, Furlong SJ, Power Coombs MR, Hoskin DW(2015). Differential Inhibition of T Lymphocyte Proliferation and Cytokine Synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-Gingerol. Phytotherapy research. 29(11):1707-1713. DOI: 10.1002/ptr.5414
  • Antiinflammatory : 10-gingerol
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 8-gingerol
11
Bernard MM, McConnery JR, Hoskin DW(2017). [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Experimental and Molecular Pathology. 102(2):370-376. DOI: 10.1016/j.yexmp.2017.03.006
  • Anti-breast cancer : 10-gingerol
  • Anti-breast cancer : 6-gingerol
  • Anti-breast cancer : 8-gingerol
  • Apoptosis inducer : 10-gingerol
  • Cytotoxic : 10-gingerol
12
Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW(2015). Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. The Journal of biological chemistry. 290(39):23553-23562. DOI: 10.1074/jbc.M115.662445
  • Anticancer : Gingerenone-a
  • Antitumor : Gingerenone-a
  • Apoptosis inducer : Gingerenone-a
13
Chakraborty D, Bishayee K, Ghosh S, Biswas R, Mandal SK, Khuda-Bukhsh AR(2012). [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: Drug–DNA interaction and expression of certain signal genes in HeLa cells. European Journal of Pharmacology. 694(3-Jan):20-29. DOI: 10.1016/j.ejphar.2012.08.001
  • Apoptosis inducer : 6-gingerol
  • Autophagy inducer : 6-gingerol
14
Chakraborty D, Mukherjee A, Sikdar S, Paul A, Ghosh S, Khuda-Bukhsh AR(2012). [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicology Letters. 210(1):34-43. DOI: 10.1016/j.toxlet.2012.01.002
  • antihyperglycemic : 6-gingerol
15
Chen CY, Cheng KC, Chang AY, Lin YT, Hseu YC, Wang HM(2012). 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 13(2):1762-1777. DOI: 10.3390/ijms13021762
  • Antioxidant : 10-shogaol
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