SpiceCom: A database of phytochemicals in major spices

Turmeric

Overview
Compounds
Activities
References
Crop: Turmeric
Total No. of activities: 67
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1
Chen C, Long L, Zhang F, Chen Q, Chen C, Yu X, Liu Q, Bao J, Long Z(2018). Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum. PLoS One. 13(3). DOI: 10.1371/journal.pone.0194284
  • Antifungal : Beta-elemene
  • Antifungal : Curcumenol
  • Antifungal : Curcumin
  • Antifungal : Curcumol
  • Antifungal : Curdione
  • Antifungal : Curzerene
  • Antifungal : Germacrone
  • Antifungal : Isocurcumenol
2
Zhao W, Zhou X, Qi G, Guo Y(2018). Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation. Journal of Biochemical and Molecular Toxicology. 32(5). DOI: 10.1002/jbt.22049
  • Anti-prostate cancer : Curcumin
3
Perna A, De Luca A, Adelfi L, Pasquale T, Varriale B, Esposito T(2018). Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line. BMC Complementary and Alternative Medicine. 18(1):63. DOI: 10.1186/s12906-018-2125-9
  • Antiinflammatory : Curcumin
  • Antioxidant : Curcumin
  • Antiproliferative : Curcumin
4
Galli GM, Da Silva AS, Biazus AH, Reis JH, Boiago MM, Topazio JP, Migliorini MJ, Guarda NS, Moresco RN, Ourique AF, Santos CG, Lopes LS, Baldissera MD, Stefani LM(2018). Feed addition of curcumin to laying hens showed anticoccidial effect, and improved egg quality and animal health. Research in Veterinary Science. 118:101-106. DOI: 10.1016/j.rvsc.2018.01.022
  • Anticoccidial : Curcumin
5
Cai‐Jun Xie, Ai‐Ping Gu, Jun Cai, Yi Wu, and Rui‐Cong Chen(2018). Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke. Brain and Behaviour. 8(2). DOI: 10.1002/brb3.921
  • Anti-apoptotic : Curcumin
  • Neuroprotective : Curcumin
6
Huang HI, Chio CC, Lin JY(2018). Inhibition of EV71 by curcumin in intestinal epithelial cells. PloS one. 13(1). DOI: 10.1371/journal.pone.0191617
  • Anti-EV71 : Curcumin
  • Antiviral : Curcumin
7
Kukula-Koch W, Grabarska A, Łuszczki J, Czernicka L, Nowosadzka E, Gumbarewicz E, Jarząb A, Audo G, Upadhyay S, Głowniak K, Stepulak A(2018). Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography. Phytotherapy Research. 32(5):933-942. DOI: 10.1002/ptr.6035
  • Anti-lung cancer : Bisdemethoxycurcumin
  • Anti-lung cancer : Demethoxycurcumin
  • Antiproliferative : Bisdemethoxycurcumin
  • Antiproliferative : Demethoxycurcumin
8
Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z(2018). Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation. Journal of Molecular Neuroscience : MN. 64(1):129-139. DOI: 10.1007/s12031-017-1006-x
  • Neuroprotective : Curcumin
9
Marini E, Di Giulio M, Magi G, Di Lodovico S, Cimarelli ME, Brenciani A, Nostro A, Cellini L, Facinelli B(2018). Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus. Phytotherapy Research. 32(3):488-495. DOI: 10.1002/ptr.5994
  • Antibiofilm : Curcumin
10
Jin M, Park SY, Shen Q, Lai Y, Ou X, Mao Z, Lin D, Yu Y, Zhang W(2018). Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells. International Journal of Molecular Medicine. 41(1):521-530. DOI: 10.3892/ijmm.2017.3217
  • Anti-neuroinflammatory : Curcumin
11
Zhao Q, Guan J, Qin Y, Ren P, Zhang Z, Lv J, Sun S, Zhang C, Mao W(2018). Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. Biomedicine & Pharmacotherapy. 97:115-119. DOI: 10.1016/j.biopha.2017.09.078
  • Antitumor : Curcumin
12
Jain A, Rani V(2018). Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts. Molecular and Cellular Biochemistry. 442(1-2):81-96. DOI: 10.1007/s11010-017-3195-6
  • Cardioprotective : Curcumin
13
Akinyemi AJ, Oboh G, Ogunsuyi O, Abolaji AO, Udofia A(2018). Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model. Metabolic Brain Disease. 33(2):369-375. DOI: 10.1007/s11011-017-0100-7
  • Antiacetylcholinesterase : Curcumin
  • Antiaging : Curcumin
14
Wang J, Li XM, Bai Z, Chi BX, Wei Y, Chen X(2018). Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. Journal of Ethnopharmacology. 210:1-9. DOI: 10.1016/j.jep.2017.06.037
  • Anti-colon cancer : Curcumol
  • Antiproliferative : Curcumol
15
Zhu X, Zhu R(2018). Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway. OncoTargets and Therapy. 11:3521-3531. DOI: 10.2147/OTT.S159236
  • Anti-laryngeal cancer : Curcumin
  • Antiproliferative : Curcumin
16
Lee YH, Song NY, Suh J, Kim DH, Kim W, Ann J, Lee J, Baek JH, Na HK, Surh YJ(2018). Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. Cancer Letters. 431:219-229. DOI: 10.1016/j.canlet.2018.05.036
  • Anti-colon cancer : Curcumin
17
Alves TF, Chaud MV, Grotto D, Jozala AF, Pandit R, Rai M, Dos Santos CA(2018). Association of Silver Nanoparticles and Curcumin Solid Dispersion: Antimicrobial and Antioxidant Properties. AAPS PharmSciTech. 19(1):225-231. DOI: 10.1208/s12249-017-0832-z
  • Antimicrobial : Curcumin
  • Antioxidant : Curcumin
18
Li X, Ma S, Yang P, Sun B, Zhang Y, Sun Y, Hao M, Mou R, Jia Y(2018). Anticancer effects of curcumin on nude mice bearing lung cancer A549 cell subsets SP and NSP cells.. Oncology letters. 16(5):6756-6762. DOI: 10.3892/ol.2018.9488
  • Anti-lung cancer : Curcumin
19
Garrido-Armas M, Corona JC, Escobar ML, Torres L, Ordóñez-Romero F, Hernández-Hernández A, Arenas-Huertero F(2018). Paraptosis in human glioblastoma cell line induced by curcumin. Toxicology in Vitro. 51:63-73. DOI: 10.1016/j.tiv.2018.04.014
  • paraptosis-inducer : Curcumin
20
Shakeri A, Ward N, Panahi Y, Sahebkar A.(2018). Anti-angiogenic activity of curcumin in cancer therapy: a narrative review.. Current vascular pharmacology. 16. DOI: 10.2174/1570161116666180209113014
  • Angiogenic : Curcumin
21
Fan Y, Chen H, Peng H, Huang F, Zhong J, Zhou J(2017). Molecular Mechanisms of Curcumin Renoprotection in Experimental Acute Renal Injury. Frontiers in pharmacology. 8:912. DOI: 10.3389/fphar.2017.00912
  • Nephroprotective : Curcumin
22
Chang M, Wu M, Li H(2017). Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN/PI3K/AKT signalling pathway. American Journal of Translational Research. 9(12):5567–5575. DOI: NoDOI3
  • Anti-hepatocellular carcinoma : Curcumin
23
Pan Y, Zhao D, Yu N, An T, Miao J, Mo F, Gu Y, Zhang D, Gao S, Jiang G(2017). Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes. Royal Society open science. 4(11):170917. DOI: 10.1098/rsos.170917
  • Antiobesity : Curcumin
24
Yan FS, Sun JL, Xie WH, Shen L, Ji HF(2017). Neuroprotective Effects and Mechanisms of Curcumin-Cu(II) and -Zn(II) Complexes Systems and Their Pharmacological Implications. Nutrients. 10(1). DOI: 10.3390/nu10010028
  • Antialzheimer's : Curcumin
  • Neuroprotective : Curcumin
25
Mou S, Zhou Z, He Y, Liu F, Gong L(2017). Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a. Oncology Letters. 14(4):4937-4942. DOI: 10.3892/ol.2017.6739
  • Anti-laryngeal cancer : Curcumin
  • Antiproliferative : Curcumin
  • Apoptosis inducer : Curcumin
26
Cheng T, Zhao Y, Li B, Cheng M, Wang J, Zhang X(2017). Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model. Mediators of Inflammation. 2017:5784374. DOI: 10.1155/2017/5784374
  • Anti-osteolysis : Curcumin
27
Zang S, Tang Q, Dong F, Liu H, Li L, Guo F, Pan X, Lin H, Zeng W, Cai Z, Zhong Q, Zang N, Zang L(2017). Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1. Oncology Reports. 38(6):3583-3591. DOI: 10.3892/or.2017.6028
  • Antitumor : Curcumol
  • Apoptosis inducer : Curcumol
28
Zhou QM, Sun Y, Lu YY, Zhang H, Chen QL, Su SB(2017). Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis. Cancer Cell International. 17:84. DOI: 10.1186/s12935-017-0453-3
  • Anti-breast cancer : Curcumin
29
Busari ZA, Dauda KA1, Morenikeji OA, Afolayan F, Oyeyemi OT, Meena J, Sahu D, Panda AK(2017). Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles. Frontiers in Pharmacology. 8:622. DOI: 10.3389/fphar.2017.00622
  • Antimalarial : Curcumin
  • Antiplasmodial : Curcumin
30
Abbaoui A, Chatoui H, El Hiba O, Gamrani H(2017). Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson’s disease. Neuroscience Letters. 660:103-108. DOI: 10.1016/j.neulet.2017.09.032
  • Neuroprotective : Curcumin
31
Tyagi AK, Prasad S, Majeed M, Aggarwal BB(2017). Calebin A, a novel component of turmeric, suppresses NF-κB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization. Phytomedicine. 34:171-181. DOI: 10.1016/j.phymed.2017.08.021
  • Antiproliferative : Calebin a
  • Apoptosis inducer : Calebin a
32
Han S, Xu J, Guo X, Huang M(2017). Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production. Clinical and Experimental Pharmacology and Physiology. 45(1):84-93. DOI: 10.1111/1440-1681.12848
  • Anti-influenza A : Curcumin
33
Chen M, Chang YY, Huang S, Xiao LH, Zhou W, Zhang LY, Li C, Zhou RP, Tang J, Lin L, Du ZY, Zhang K(2017). Aromatic‐Turmerone Attenuates LPS‐Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4‐Dependent Signaling Pathway. Molecular Nutrition & Food Research. 62(2). DOI: 10.1002/mnfr.201700281
  • Anti-neuroinflammatory : Ar-turmerone
34
Wang XP, Wang QX, Lin HP, Chang N(2017). Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma. Food & Function. 8(9):3319-3326. DOI: 10.1039/c7fo00555e
  • Antiproliferative : Curcumin
  • Antitumor : Curcumin
35
Chen C, Jin S, Xiang X, Wang X, Shi Q, Yang M, Ji S, Huang R, Song C(2017). Enrichment and Cytotoxic Activity of Curcuminoids from Turmeric Using Macroporous Resins. Journal of Food Science. 82(9):2024-2030. DOI: 10.1111/1750-3841.13800
  • Cytotoxic : Bisdemethoxycurcumin
  • Cytotoxic : Curcumin
  • Cytotoxic : Demethoxycurcumin
36
Messner DJ, Surrago C, Fiordalisi C, Chung WY, Kowdley KV(2017). Isolation and characterization of iron chelators from turmeric (Curcuma longa): selective metal binding by curcuminoids. BioMetals. 30(5):699-708. DOI: 10.1007/s10534-017-0038-6
  • Metal-Chelator : Curcumin
37
Ortega-Domínguez B, Aparicio-Trejo OE, García-Arroyo FE, León-Contreras JC3, Tapia E2, Molina-Jijón E1, Hernández-Pando R, Sánchez-Lozada LG, Barrera-Oviedo D, Pedraza-Chaverri J(2017). Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic. Food and Chemical Toxicology. 107(Part A):373-385. DOI: 10.1016/j.fct.2017.07.018
  • Renoprotective : Curcumin
38
Darbinyan LV, Hambardzumyan LE, Simonyan KV, Chavushyan VA, Manukyan LP, Badalyan SA, Khalaji N, Sarkisian VH(2017). Protective effects of curcumin against rotenone-induced rat model of Parkinson’s disease: in vivo electrophysiological and behavioral study. Metabolic Brain Disease. 32(6):1791–1803. DOI: 10.1007/s11011-017-0060-y
  • Neuroprotective : Curcumin
39
Huang L, Li A, Liao G, Yang F, Yang J, Chen X, Jiang X(2017). Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA. Oncology Letters. 14(1):1080-1088. DOI: 10.3892/ol.2017.6273
  • Anti-breast cancer : Curcumol
  • Apoptosis inducer : Curcumol
40
Frank A, Abu-Lafi S, Adawi A, Schwed JS, Stark H, Rayan A(2017). From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation.. Inflammation research :. 66(10):923-929. DOI: 10.1007/s00011-017-1075-x
  • Antiinflammatory : Bisdemethoxycurcumin
  • Antiinflammatory : Bisdemethoxycurcumin
41
Lee HY, Kim SW, Lee GH, Choi MK, Chung HW, Lee YC, Kim HR, Kwon HJ, Chae H(2017). Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress. Scientific Letters. 7(1):6513. DOI: 10.1038/s41598-017-06872-y
  • Hepatoprotective : Curcumin
42
Rivera M, Ramos Y, Rodríguez-Valentín M, López-Acevedo S, Cubano LA, Zou J, Zhang Q, Wang G, Boukli NM(2017). Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells. PLoS One. 12(6). DOI: 10.1371/journal.pone.0179587
  • Anti-prostate cancer : Curcumin
  • Cytotoxic : Curcumin
43
Wang X, Deng J, Yuan J, Tang X, Wang Y, Chen H, Liu Y, Zhou L(2017). Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells. International Journal of Oncology. 51(2):467-477. DOI: 10.3892/ijo.2017.4037
  • Antiglioma : Curcumin
  • Antiproliferative : Curcumin
  • Antitumor : Curcumin
44
Kádasi A, Maruniaková N, Štochmaľová A, Bauer M, Grossmann R, Harrath AH, Kolesárová A, Sirotkin AV(2017). Direct effect of curcumin on porcine ovarian cell functions. Animal Reproduction Science. 182:77-83. DOI: 10.3892/ijo.2017.403710.1016/j.anireprosci.2017.05.001
  • Anti-gonadal : Curcumin
45
Park E, Chun HS(2017). Protective Effects of Curcumin on Manganese-Induced BV-2 Microglial Cell Death. Biological and Pharmaceutical Bulletin. 40(8):1275-1281. DOI: 10.1248/bpb.b17-00160
  • Cytoprotective : Curcumin
46
Loganes C, Lega S, Bramuzzo M, Vecchi Brumatti L, Piscianz E, Valencic E, Tommasini A, Marcuzzi A(2017). Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage. Nutrients. 9(6):E578. DOI: 10.3390/nu9060578
  • Antiapoptotic : Curcumin
47
Akinyemi AJ, Oboh G, Fadaka AO, Olatunji BP, Akomolafe S(2017). Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. NeuroToxicology. 62:75-79. DOI: 10.1016/j.neuro.2017.05.004
  • Antiacetylcholinesterase : Curcumin
48
Yang X, Jiang H, Shi Y(2017). Upregulation of heme oxygenase-1 expression by curcumin conferring protection from hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblasts. Cell & Bioscience. 7:20. DOI: 10.1186/s13578-017-0146-6
  • Antiapoptotic : Curcumin
49
Ramkumar M, Rajasankar S, Gobi VV, Dhanalakshmi C, Manivasagam T, Justin Thenmozhi A, Essa MM4, Kalandar A, Chidambaram R(2017). Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells. BMC Complementary and Alternative Medicine. 17(1):217. DOI: 10.1186/s12906-017-1720-5
  • Neuroprotective : Demethoxycurcumin
50
Liu YM, Zhang QZ, Xu DH, Fu YW, Lin DJ, Zhou SY, Li JP(2017). Antiparasitic efficacy of curcumin from Curcuma longa against Ichthyophthirius multifiliis in grass carp. Veterinary Parasitology. 236:128-136. DOI: 10.1016/j.vetpar.2017.02.011
  • Antiparasitic : Curcumin
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