SpiceCom: A database of phytochemicals in major spices

Ginger

Overview
Compounds
Activities
References
Crop: Ginger
Total No. of activities: 94
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1
Joo JH, Hong SS, Cho YR, Seo DW(2016). 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncology Reports. 35(2):779-784. DOI: 10.3892/or.2015.4405
  • Antiinvasive : 10-gingerol
  • Antiproliferative : 10-gingerol
  • Antitumor : 10-gingerol
2
Chen CY, Cheng KC, Chang AY, Lin YT, Hseu YC, Wang HM(2012). 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 13(2):1762-1777. DOI: 10.3390/ijms13021762
  • Antioxidant : 10-shogaol
3
Abdel-Aziz H, Nahrstedt A, Petereit F, Windeck T, Ploch M, Verspohl EJ(2005). 5-HT3 Receptor Blocking Activity of Arylalkanes Isolated from the Rhizome of Zingiber officinale. Planta Medica. 71(7):609-616. DOI: 10.1055/s-2005-871265
  • Anti-5-HT : 10-gingerol
  • Anti-5-HT : 4-gingerol
  • Anti-5-HT : 6-dehydrogingerdione
  • Anti-5-HT : 6-gingerol
  • Anti-5-HT : 6-shogaol
  • Anti-5-HT : 8-gingerol
  • Anti-5-HT : 8-shogaol
4
Hsu YL, Chen CY, Hou MF, Tsai EM, Jong YJ, Hung CH, Kuo PL(2010). 6‐Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c‐Jun N‐terminal kinase pathways in human breast cancer cells. Molecular Nutrition & Food Research. 54(9):1307-17. DOI: 10.1002/mnfr.200900125
  • Anti-breast cancer : 6-dehydrogingerdione
  • Apoptosis inducer : 6-dehydrogingerdione
5
El-Bakly WM, Louka ML, El-Halawany AM, Schaalan MF(2012). 6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation. Cancer Chemotherapy and Pharmacology. 70(6):833-841. DOI: 10.1007/s00280-012-1975-y
  • Cardioprotective : 6-gingerol
6
Wang S, Tian M, Yang R, Jing Y, Chen W, Wang J, Zheng X, Wang F(2018). 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE−/− Mice Exposed to Chronic Mild Stress. Cardiovascular Toxicology. :11-Jan. DOI: 10.1007/s12012-018-9452-4
  • Antiatherosclerotic : 6-gingerol
7
Yang G, Wang S, Zhong L, Dong X, Zhang W, Jiang L, Geng C, Sun X, Liu X, Chen M, Ma Y(2012). 6-Gingerol Induces Apoptosis through Lysosomal‐Mitochondrial Axis in Human Hepatoma G2 Cells. Phytotherapy research. 26(11):1667-1673. DOI: 10.1002/ptr.4632
  • Apoptosis inducer : 6-gingerol
8
Wang S, Sun X, Jiang L, Liu X, Chen M, Yao X, Sun Q, Yang G(2016). 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chemico-Biological Interactions. 256:249-56. DOI: 10.1016/j.cbi.2016.07.020
  • Antiapoptotic : 6-gingerol
  • Autophagy inducer : 6-gingerol
9
Lin CB, Lin CC, Tsay GJ(2012). 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest. Evidence-Based Complementary and Alternative Medicine. 2012:326096. DOI: 10.1155/2012/326096
  • Anti-colon cancer : 6-gingerol
10
Fan J, Yang X, Bi Z(2015). 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumor Biology. 36(2):1135-1141. DOI: 10.1007/s1327
  • Anticancer : 6-gingerol
  • Apoptosis inducer : 6-gingerol
11
Pallashri Saha, Atul Katarkar, Bornita Das, Aritra Bhattacharyya & KeyaChaudhuri(2015). 6-Gingerol inhibits Vibrio cholerae-inducedproinflammatory cytokines in intestinal epithelialcells via modulation of NF-κB. Pharmaceutical Biology. 54(9). DOI: 10.3109/13880209.2015.1110598
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
12
Yang G, Zhong L, Jiang L, Geng C, Cao J, Sun X, Liu X, Chen M, Ma Y(2011). 6-Gingerol Prevents Patulin‐induced Genotoxicity in HepG2 Cells. Phytotherapy Research. 25(10):1480-1485. DOI: 10.1002/ptr.3446
  • Chemoprotective : 6-gingerol
13
Kim HS, Lee SH, Byun Y, Park HD(2015). 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Scientific reports. 5:8656. DOI: 10.1038/srep08656
  • Antibiofilm : 6-gingerol
14
Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh, Fang-Rong Chang(2017). 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. International Journl of Molecular Sciences. 18(1). DOI: 10.3390/ijms18010168
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-shogaol
  • Antiobesity : 6-paradol
15
Chen CY, Liu TZ, Liu YW, Tseng WC, Liu RH, Lu FJ, Lin YS, Kuo SH, Chen CH(2007). 6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an Oxidative Stress-Mediated Caspase-Dependent Mechanism. Journal of Agricultural and Food Chemistry. 55(3):948-954. DOI: 10.1021/jf0624594
  • Apoptosis inducer : 6-shogaol
16
Han Q, Yuan Q, Meng X, Huo J, Bao Y, Xie G(2017). 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-Y. Oncotarget. 8(26):42001-42006. DOI: 10.18632/oncotarget.16719
  • Antiinflammatory : 6-shogaol
17
Kim SM, Kim C, Bae H, Lee JH, Baek SH, Nam D, Chung WS, Shim BS, Lee SG, Kim SH, Sethi G, Ahn KS(2015). 6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways. Molecular Carcinogenesis. 54(10):1132-46. DOI: 10.1002/mc.22184
  • Anticancer : 6-shogaol
  • Antiproliferative : 6-shogaol
  • Antitumor : 6-shogaol
  • Apoptosis inducer : 6-shogaol
18
Saha A, Blando J, Silver E, Beltran L, Sessler J, DiGiovanni J(2014). 6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling. Cancer Prevention Research. 7(6):627-38. DOI: 10.1158/1940-6207.CAPR-13-0420
  • Apoptosis inducer : 6-shogaol
  • Chemopreventive : 6-shogaol
19
Na JY, Song K, Lee JW, Kim S, Kwon J(2016). 6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer's disease via CysLT1R-mediated inhibition of cathepsin B. Biochemical and Biophysical Research Communications. 477(1):96-102. DOI: 10.1016/j.bbrc.2016.06.026
  • Anti-amyloidogenic : 6-shogaol
  • Antialzheimer's : 6-shogaol
  • Neuroprotective : 6-shogaol
20
Kotowski U, Kadletz L, Schneider S, Foki E, Schmid R, Seemann R3, Thurnher D, Heiduschka G(2018). 6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines. Phytotherapy research. 32(2):340-347. DOI: 10.1002/ptr.5982
  • Apoptosis inducer : 6-gingerol
  • Apoptosis inducer : 6-shogaol
21
Pan MH, Hsieh MC, Kuo JM, Lai CS, Wu H, Sang S, Ho CT(2008). 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Molecular Nutrition & Food Research. 52(5):527-537. DOI: 10.1002/mnfr.200700157
  • Apoptosis inducer : 6-shogaol
22
Hu R, Zhou P, Peng YB, Xu X, Ma J, Liu Q, Zhang L, Wen XD, Qi LW, Gao N, Li P(2012). 6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells and Exhibits Anti-Tumor Activity In Vivo through Endoplasmic Reticulum Stress. PLOS ONE. 7(6):e39664. DOI: 10.1371/journal.pone.0039664
  • Antitumor : 6-shogaol
  • Apoptosis inducer : 6-shogaol
23
Liu Q, Peng YB, Zhou P, Qi LW, Zhang M, Gao N, Liu EH, Li P(2013). 6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α.. Molecular cancer. 12(1):135. DOI: 10.1186/1476-4598-12-135
  • Antileukemia : 6-shogaol
  • Antitumor : 6-shogaol
  • Apoptosis inducer : 6-shogaol
24
Li TY, Chiang BH(2017). 6-shogaol induces autophagic cell death then triggered apoptosis in colorectal adenocarcinoma HT-29 cells. Biomedicine & Pharmacotherapy. 93:208-217. DOI: 10.1016/j.biopha.2017.06.038
  • Apoptosis inducer : 6-shogaol
  • Autophagy inducer : 6-shogaol
25
Nedungadi D, Binoy A, Pandurangan N1, Pal S, Nair BG, Mishra N(2018). 6-Shogaol induces caspase-independent paraptosis in cancer cells via proteasomal inhibition. Experimental Cell Research. 364(2):243-251. DOI: 10.1016/j.yexcr.2018.02.018
  • Anticancer : 6-shogaol
  • paraptosis-inducer : 6-shogaol
26
Wu JJ, Omar HA, Lee YR, Teng YN, Chen PS, Chen YC, Huang HS, Lee KH, Hung JH(2015). 6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms. European Journal of Pharmacology. 762:449-58. DOI: 10.1016/j.ejphar.2015.06.032
  • Anti-liver cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Autophagy inducer : 6-shogaol
27
Ray A, Vasudevan S, Sengupta S(2015). 6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death. PLOS ONE. 10(9):e0137614. DOI: 10.1371/journal.pone.0137614
  • Anti-breast cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Autophagy inducer : 6-shogaol
28
Villalvilla A, da Silva JA, Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R(2014). 6-Shogaol inhibits chondrocytes’ innate immune responses and cathepsin‐K activity . Molecular nutrition & food research. 58(2):256-266. DOI: 10.1002/mnfr.201200833
  • Antiinflammatory : 6-shogaol
29
Sabina EP, Rasool M, Mathew L, Ezilrani P, Indu H(2010). 6-Shogaol inhibits monosodium urate crystal-induced inflammation – An in vivo and in vitro study. Food and Chemical Toxicology. 48(1):229-235. DOI: 10.1016/j.fct.2009.10.005
  • Anti-gouty arthritis : 6-shogaol
  • Antiinflammatory : 6-shogaol
30
Wang YK, Hong YJ, Yao YH, Huang XM, Liu XB, Zhang CY, Zhang L, Xu XL(2013). 6-Shogaol Protects against Oxidized LDL-Induced Endothelial Injruries by Inhibiting Oxidized LDL-Evoked LOX-1 Signaling. Evidence-based complementary and alternative medicine : eCAM. 2013:503521. DOI: 10.1155/2013/503521
  • Antiapoptotic : 6-shogaol
  • Antiatherosclerotic : 6-shogaol
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