SpiceCom: A database of phytochemicals in major spices

Ginger

Overview
Compounds
Activities
References
Crop: Ginger
Total No. of activities: 94
Sort by: Authors    
Per page: 30
<<First Page
of 5 Next> Last>>
1
Abdel-Aziz H, Nahrstedt A, Petereit F, Windeck T, Ploch M, Verspohl EJ(2005). 5-HT3 Receptor Blocking Activity of Arylalkanes Isolated from the Rhizome of Zingiber officinale. Planta Medica. 71(7):609-616. DOI: 10.1055/s-2005-871265
  • Anti-5-HT : 10-gingerol
  • Anti-5-HT : 4-gingerol
  • Anti-5-HT : 6-dehydrogingerdione
  • Anti-5-HT : 6-gingerol
  • Anti-5-HT : 6-shogaol
  • Anti-5-HT : 8-gingerol
  • Anti-5-HT : 8-shogaol
2
Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ(2006). Mode of action of gingerols and shogaols on 5-HT3 receptors: Binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. European Journal of Pharmacology. 530(2-Jan):136-143. DOI: 10.1016/j.ejphar.2005.10.049
  • Anticholinergic : 10-gingerol
  • Anticholinergic : 6-gingerol
  • Anticholinergic : 6-shogaol
  • Anticholinergic : 8-gingerol
  • Antiemetic : 10-gingerol
  • Antiemetic : 6-gingerol
  • Antiemetic : 6-shogaol
  • Antiemetic : 8-gingerol
  • Antineurokininergic : 10-gingerol
  • Antineurokininergic : 6-gingerol
  • Antineurokininergic : 6-shogaol
  • Antineurokininergic : 8-gingerol
3
Agarwal M, Walia S, Dhingra S, Khambay BP(2001). Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes. Pest Management Science. 57(3):289-300. DOI: 10.1002/ps.263
  • Antifeedant : 6-gingerol
  • Antifungal : Dehydrozingerone
  • Insect growth regulatory : [6]-dehydroshogaol
4
Ajayi BO, Adedara IA, Farombi EO(2018). Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice. Human & Experimental Toxicology. January. DOI: 10.1177/0960327117751235
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
  • Antiulcer : 6-gingerol
  • NF-kB-Inhibitor : 6-gingerol
5
Ajayi BO, Adedara IA, Farombi EO(2015). Pharmacological Activity of 6-Gingerol in Dextran Sulphate Sodium-induced Ulcerative Colitis in BALB/c Mice. Phytotherapy research. 29(4):566-572. DOI: 10.1002/ptr.5286
  • Anticolitic : 6-gingerol
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
6
Alibakhshi T, Khodayar MJ, Khorsandi L, Rashno M, Zeidooni L(2018). Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomedicine & Pharmacotherapy. 105:225–232. DOI: 10.1016/j.biopha.2018.05.085
  • Nephroprotective : Gingerone
7
Amri M, Touil-Boukoffa C(2016). In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol. Asian Pacific Journal of Tropical Medicine. 9(8):749-756. DOI: 10.1016/j.apjtm.2016.06.013
  • Antihydatic : 6-gingerol
  • Cytotoxic : 6-gingerol
  • Immunomodulatory : 6-gingerol
  • Larvicidal : 6-gingerol
8
Annamalai G, Kathiresan S, Kannappan N(2016). [6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells. Biomedicine & Pharmacotherapy. 82:226-236. DOI: 10.1016/j.biopha.2016.04.044
  • Anti-laryngeal cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Cytotoxic : 6-shogaol
9
Annamalai G, Suresh K(2018). [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis. Biomedicine & Pharmacotherapy. 98:484-490. DOI: 10.1016/j.biopha.2017.12.009
  • Antiinflammatory : 6-shogaol
  • Antitumorigenic : 6-shogaol
  • NF-kB-Inhibitor : 6-shogaol
10
Bernard M, Furlong SJ, Power Coombs MR, Hoskin DW(2015). Differential Inhibition of T Lymphocyte Proliferation and Cytokine Synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-Gingerol. Phytotherapy research. 29(11):1707-1713. DOI: 10.1002/ptr.5414
  • Antiinflammatory : 10-gingerol
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 8-gingerol
11
Bernard MM, McConnery JR, Hoskin DW(2017). [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Experimental and Molecular Pathology. 102(2):370-376. DOI: 10.1016/j.yexmp.2017.03.006
  • Anti-breast cancer : 10-gingerol
  • Anti-breast cancer : 6-gingerol
  • Anti-breast cancer : 8-gingerol
  • Apoptosis inducer : 10-gingerol
  • Cytotoxic : 10-gingerol
12
Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW(2015). Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. The Journal of biological chemistry. 290(39):23553-23562. DOI: 10.1074/jbc.M115.662445
  • Anticancer : Gingerenone-a
  • Antitumor : Gingerenone-a
  • Apoptosis inducer : Gingerenone-a
13
Chakraborty D, Bishayee K, Ghosh S, Biswas R, Mandal SK, Khuda-Bukhsh AR(2012). [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: Drug–DNA interaction and expression of certain signal genes in HeLa cells. European Journal of Pharmacology. 694(3-Jan):20-29. DOI: 10.1016/j.ejphar.2012.08.001
  • Apoptosis inducer : 6-gingerol
  • Autophagy inducer : 6-gingerol
14
Chakraborty D, Mukherjee A, Sikdar S, Paul A, Ghosh S, Khuda-Bukhsh AR(2012). [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicology Letters. 210(1):34-43. DOI: 10.1016/j.toxlet.2012.01.002
  • antihyperglycemic : 6-gingerol
15
Chen CY, Cheng KC, Chang AY, Lin YT, Hseu YC, Wang HM(2012). 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 13(2):1762-1777. DOI: 10.3390/ijms13021762
  • Antioxidant : 10-shogaol
16
Chen CY, Liu TZ, Liu YW, Tseng WC, Liu RH, Lu FJ, Lin YS, Kuo SH, Chen CH(2007). 6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an Oxidative Stress-Mediated Caspase-Dependent Mechanism. Journal of Agricultural and Food Chemistry. 55(3):948-954. DOI: 10.1021/jf0624594
  • Apoptosis inducer : 6-shogaol
17
Chen JC, Huang LJ, Wu SL, Kuo SC, Ho TY, Hsiang CY(2007). Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice. Journal of Agricultural and Food Chemistry. 55(21):8390-8397. DOI: 10.1021/jf071460f
  • Antidiarrheal : Gingerone
18
Cheong KO, Shin DS, Bak J, Lee C, Kim KW, Je NK, Chung HY, Yoon S, Moon JO(2016). Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. Archives of Pharmacal Research. 39(2):279–291. DOI: 10.1007/s12272-015-0696-2
  • Antifibrotic : Gingerone
  • Antiinflammatory : Gingerone
  • Antioxidant : Gingerone
  • Hepatoprotective : Gingerone
  • NF-kB-Inhibitor : Gingerone
19
Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh, Fang-Rong Chang(2017). 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. International Journl of Molecular Sciences. 18(1). DOI: 10.3390/ijms18010168
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-shogaol
  • Antiobesity : 6-paradol
20
Chunbo Li, Lin Zhou(2015). Inhibitory effect 6-gingerol on adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes. Toxicology in Vitro. 30(1):394-401. DOI: 10.1016/j.tiv.2015.09.023
  • antiadipogenic : 6-gingerol
21
Cui Y, Shi Y, Bao Y, Wang S, Hua Q, Liu Y(2018). Zingerone attenuates diabetic nephropathy through inhibition of nicotinamide adenine dinucleotide phosphate oxidase 4. Biomedicine & Pharmacotherapy. 99:422-430. DOI: 10.1016/j.biopha.2018.01.051
  • Nephroprotective : Gingerone
22
Cuya T, Baptista L, Celmar Costa França T(2017). A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease.. Journal of biomolecular structure & dynamics. :13-Jan. DOI: 10.1080/07391102.2017.1401004
  • Antiacetylcholinesterase : Gingerenone-a
23
Denyer CV, Jackson P, Loakes DM, Ellis MR, Young DA(1994). Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale). Journal of Natural Products. 57(5):658-652. DOI: 10.1021/np50107a017
  • Antirhinoviral : Sesquiphellandrene
24
Dugasani S1, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN(2010). Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of Ethnopharmacology. 127(2):515-520. DOI: 10.1016/j.jep.2009.10.004
  • Antiinflammatory : 10-gingerol
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-shogaol
  • Antiinflammatory : 8-gingerol
25
El-Bakly WM, Louka ML, El-Halawany AM, Schaalan MF(2012). 6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation. Cancer Chemotherapy and Pharmacology. 70(6):833-841. DOI: 10.1007/s00280-012-1975-y
  • Cardioprotective : 6-gingerol
26
Etoh H, Kondoh T, Noda R, Singh IP, Sekiwa Y, Morimitsu K, Kubota K(2002). Shogaols from Zingiber officinale as Promising Antifouling Agents. Bioscience, Biotechnology, and Biochemistry . 66(8):1748-1750. DOI: 10.1271/bbb.66.1748
  • Antifouling : 8-shogaol
27
Ezzat SM, Ezzat MI, Okba MM, Menze ET, Abdel-Naim AB(2018). The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. Journal of Ethnopharmacology. 214:113-123. DOI: 10.1016/j.jep.2017.12.019
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-paradol
  • Antiinflammatory : 6-shogaol
  • Antilipoxygenase : 6-gingerol
  • Antilipoxygenase : 6-shogaol
28
Fan J, Yang X, Bi Z(2015). 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumor Biology. 36(2):1135-1141. DOI: 10.1007/s1327
  • Anticancer : 6-gingerol
  • Apoptosis inducer : 6-gingerol
29
Ficker C, Smith ML, Akpagana K, Gbeassor M, Zhang J, Durst T, Assabgui R, Arnason JT(2003). Bioassay-guided isolation and identification of antifungal compounds from ginger. Phytotherapy Research. 17(8):897-902. DOI: 10.1002/ptr.1335
  • Antifungal : 10-gingerol
  • Antifungal : 6-gingerdiol
  • Antifungal : 6-gingerol
  • Antifungal : 8-gingerol
30
Ghayur MN, Gilani AH, Afridi MB, Houghton PJ(2005). Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascular Pharmacology. 43(4):234-241. DOI: 10.1016/j.vph.2005.07.003
  • Vasodilator : 10-gingerol
  • Vasodilator : 6-gingerol
  • Vasodilator : 6-shogaol
  • Vasodilator : 8-gingerol
<<First Page
of 5 Next> Last>>


Designed and developed by Bioinformatics Centre, ICAR-IISR

Copyright©2018 ICAR-Indian Institute of Spices Research

Useful links : PubMed PubChem PDB ChemSpider Jmol ICAR DBT