SpiceCom: A database of phytochemicals in major spices

Cinnamon

Overview
Compounds
Activities
References
Crop: Cinnamon
Total No. of activities: 46
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1
Connell BJ, Chang SY, Prakash E, Yousfi R, Mohan V, Posch W, Wilflingseder D, Moog C, Kodama EN7, Clayette P, Lortat-Jacob H(2016). A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.. PloS one. 11(10). DOI: 10.1371/journal.pone.0165386
  • AntiHIV : Ind02-trimer
2
Yoo W, Yoo D, Hong E, Jung E, Go Y, Singh SVB, Khang G, Lee D3(2018). Acid-activatable oxidative stress-inducing polysaccharide nanoparticles for anticancer therapy.. Journal of controlled release : official journal of the Controlled Release Society. 269:235-244. DOI: 10.1016/j.jconrel.2017.11.023
  • Anticancer : Cinnamaldehyde
3
KentaroTsuji-Naito(2008). Aldehydic components of Cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation. Bioorganic & Medicinal Chemistry. 16(20):9176-9183. DOI: 10.1016/j.bmc.2008.09.036
  • Osteoclastogenesis inbitor : 2-methoxycinnamaldehyde
  • Osteoclastogenesis inbitor : Cinnamaldehyde
4
Williams AR, Ramsay A, Hansen TV, Ropiak HM, Mejer H, Nejsum P, Mueller-Harvey I, Thamsborg SM(2015). Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum). Scientific reports. 5:14791. DOI: 10.1038/srep14791
  • Anthelmintic : Cinnamaldehyde
5
Gunawardena D1, Karunaweera N, Lee S, van Der Kooy F, Harman DG, Raju R, Bennett L, Gyengesi E, Sucher NJ, Münch G(2015). Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - Identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds. Food & Function. 6(3). DOI: 10.1039/c4fo00680a
  • Antiinflammatory : 2-methoxycinnamaldehyde
  • Antiinflammatory : Cinnamaldehyde
6
Fraňková A1, Marounek M, Mozrová V, Weber J, Klouček P, Lukešová D(2014). Antibacterial activities of plant-derived compounds and essential oils toward Cronobacter sakazakii and Cronobacter malonaticus.. Foodborne Pathogens and Disease. 11(10):795-7. DOI: 10.1089/fpd.2014.1737
  • Antibacterial : Cinnamaldehyde
7
Yue Wang, Yi Zhang, Yan-qin Shi, Xian-hua Pan, Yan-hua Lu, Ping Cao(2018). Antibacterial effects of cinnamon (Cinnamomum zeylanicum) bark essential oil on Porphyromonas gingivalis. Microbial Pathogenesis. 116:26-32. DOI: 10.1016/j.micpath.2018.01.009
  • Antibacterial : Cinnamaldehyde
  • Antibiofilm : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
8
Kot B, Wicha J, Piechota M, Wolska K, Gruzewska A(2015). Antibiofilm activity of trans-cinnamaldehyde, p-coumaric, and ferulic acids on uropathogenic Escherichia coli.. Turkish journal of medical sciences. 45(4):919-24. DOI: 10.3906/sag-1406-112
  • Antibiofilm : Cinnamaldehyde
9
Abhinav Upadhyay, Indu Upadhyaya, Anup Kollanoor-Johny, Kumar Venkitanarayanan(2013). Antibiofilm effect of plant derived antimicrobials on Listeria monocytogenes. Food Microbiology. 36(1):79-89. DOI: 10.1016/j.fm.2013.04.010
  • Antibiofilm : Cinnamaldehyde
10
Mary Anne Roshni, Amalaradjou Amoolya Narayanan, Sangeetha Ananda Baskaran, Kumar Venkitanarayanan(2010). Antibiofilm Effect of Trans-Cinnamaldehyde on Uropathogenic Escherichia coli. The Journal of Urology. 1(184):358-363. DOI: 10.1016/j.juro.2010.03.006
  • Antibiofilm : Cinnamaldehyde
11
Sen-SungCheng, Ju-YunLiu, Ed-HaunChang, Shang-TzenChang(2008). Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi. Bioresource Technology. 99(11):5145-5149. DOI: 10.1016/j.biortech.2007.09.013
  • Antifungal : Cinnamaldehyde
12
Homa M, Fekete IP, Böszörményi A, Singh YR, Selvam KP, Shobana CS, Manikandan P6, Kredics L, Vágvölgyi C, Galgóczy L(2015). Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates. Planta Medica. 81(14):1277-84. DOI: 10.1055/s-0035-1546272
  • Antifungal : Cinnamaldehyde
13
Shaik Mahaboob Ali, Aleem A Khan, Irshad Ahmed, M Musaddiq, Khaja S Ahmed, H Polasa, L Venkateswar Rao, Chittoor M Habibullah, Leonardo A Sechi, Niyaz Ahmed(2005). Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Annals of Clinical Microbiology and Antimicrobials. 4(20). DOI: 10.1186/1476-0711-4-20
  • Antibacterial : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
14
Liesel Brenda Gende, Ignazio Floris, Rosalia Fritz, Martin Javier Eguaras(2008). Antimicrobial activity of cinnamon(Cinnamomum zeylanicum) essential oil and its main components against Paenibacillus larvae from Argentine. Bulletin of Insectology. 61(1):4-Jan. DOI: NoDOI1
  • Antibacterial : Cinnamaldehyde
  • Antibacterial : Eugenol
  • Antimicrobial : Cinnamaldehyde
  • Antimicrobial : Eugenol
15
Naveed R, Hussain I, Tawab A, Tariq M, Rahman M, Hameed S, Mahmood MS, Siddique AB, Iqbal M(2013). Antimicrobial activity of the bioactive components of essential oils from Pakistani spices against Salmonella and other multi-drug resistant bacteria. BMC Complementary and Alternative Medicine. 13(265). DOI: 10.1186/1472-6882-13-265
  • Antimicrobial : Cinnamaldehyde
16
Monteiro IN, Monteiro ODS, Costa-Junior LM, da Silva Lima A, Andrade EHA, Maia JGS, Mouchrek Filho VE.(2017). Chemical composition and acaricide activity of an essential oil from a rare chemotype of Cinnamomum verum Presl on Rhipicephalus microplus (Acari: Ixodidae).. Vet Parasitol.. 238:00:00(-):54-57. DOI: 10.1016/j.vetpar.2017.03.016
  • Acaricide : Benzyl-benzoate
  • Acaricide : Eugenol
17
Hagenlocher Y, Kiessling K, Schäffer M, Bischoff SC, Lorentz A(2015). Cinnamaldehyde is the main mediator of cinnamon extract in mast cell inhibition.. European journal of nutrition. 54(8):1297-309. DOI: 10.1007/s00394-014-0810-0
  • Antiallergic : Cinnamaldehyde
18
Mendes SJ, Sousa FI, Pereira DM, Ferro TA, Pereira IC, Silva BL, Pinheiro AJ, Mouchrek AQ, Monteiro-Neto V, Costa SK, Nascimento JL, Grisotto MA, da Costa R, Fernandes ES(2016). Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms. International Immunopharmacology. 34:60-70. DOI: 10.1016/j.intimp.2016.02.012
  • Immunomodulatory : Cinnamaldehyde
19
Hosni AA, Abdel-Moneim AA, Abdel-Reheim ES, Mohamed SM, Helmy H(2017). Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARγ, proinflammatory cytokines and oxidative stress.. Biomedicine & Pharmacotherapy. 88:52-60. DOI: 10.1016/j.biopha.2017.01.054
  • Hypoglycemic : Cinnamaldehyde
20
Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, Lee JY(2008). Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochemical pharmacology. 75(2):494-502. DOI: 10.1016/j.bcp.2007.08.033
  • Antiinflammatory : Cinnamaldehyde
21
Subash Babu P, Prabuseenivasan S, Ignacimuthu S(2007). Cinnamaldehyde—A potential antidiabetic agent. Phytomedicine. 14(1):15-22. DOI: 10.1016/j.phymed.2006.11.005
  • Antidiabetic : Cinnamaldehyde
  • antihyperglycemic : Cinnamaldehyde
  • Hypoglycemic : Cinnamaldehyde
  • Hypolipidemic : Cinnamaldehyde
22
Wong HY, Tsai KD1, Liu YH, Yang SM1,, Chen TW, Cherng J, Chou KS, Chang CM, Yao BT, Cherng JM(2016). Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytotherapy research : PTR. 30(2):331-40. DOI: 10.1002/ptr.5536
  • Anticancer : 2-methoxycinnamaldehyde
  • Antiproliferative : 2-methoxycinnamaldehyde
  • Chemopreventive : 2-methoxycinnamaldehyde
  • NF-kB-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-I-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-II-Inhibitor : 2-methoxycinnamaldehyde
23
Yong-Guy Kim, Jin-Hyung Lee, Soon-Il Kim, Kwang-Hyun Baek, Jintae Lee(2015). Cinnamon bark oil and its components inhibit biofilm formation and toxin production. International Journal of Food Microbiology. 195:30-39. DOI: 10.1016/j.ijfoodmicro.2014.11.028
  • Antibiofilm : Cinnamaldehyde
  • Antibiofilm : Eugenol
  • Antihemolytic : Cinnamaldehyde
  • Antihemolytic : Eugenol
24
Tina Sartorius, Andreas Peter, Nadja Schulz, Andrea Drescher, Ina Bergheim, Jürgen Machann, Fritz Schick, Dorothea Siegel-Axel, Annette Schürmann, Cora Weigert, Hans-Ulrich Häring, Anita M. Hennige(2014). Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity. PLOS ONE. 9(3). DOI: 10.1371/journal.pone.0092358
  • Antidiabetic : Eugenol
25
Takasao N, Tsuji-Naito K, Ishikura S, Tamura A, Akagawa M(2012). Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts.. Journal of agricultural and food chemistry. 60(5):1193-200. DOI: 10.1021/jf2043357
  • Antiaging : Cinnamaldehyde
26
El-Sayed el-SM, Abd El-Raouf OM, Fawzy HM, Manie MF(2013). Comparative study of the possible protective effects of cinnamic acid and cinnamaldehyde on cisplatin-induced nephrotoxicity in rats.. Journal of biochemical and molecular toxicology. 27(12):508-514. DOI: 10.1002/jbt.21515
  • Nephroprotective : Cinnamaldehyde
  • Nephroprotective : Cinnamic-acid
27
Usta J, Kreydiyyeh S, Barnabe P, Bou-Moughlabay Y, Nakkash-Chmaisse H(2003). Comparative study on the effect of cinnamon and clove extracts and their main components on different types of ATPases.. Human & experimental toxicology. 22(7):355-62. DOI: 10.1191/0960327103ht379oa
  • ATPase-Inhibitor : Cinnamaldehyde
28
Ibrahim bin Jantan, Bushra Abdul Karim Moharam, Jacintha Santhanam, Jamia Azdina Jamal(2008). Correlation Between Chemical Composition and Antifungal Activity of the Essential Oils of Eight Cinnamomum. Species. Pharmaceutical Biology. 46(6):406-412. DOI: 10.1080/13880200802055859
  • Antifungal : Cinnamaldehyde
  • Antifungal : Eugenol
29
Kuen-daw Tsai, Yi-Heng Liu, Ta-Wei Chen, Shu-Mei Yang, Ho-Yiu Wong, Jonathan Cherng, Kuo-Shen Chou, Jaw-Ming Cherng(2016). Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells. Nutrients. 8(6). DOI: 10.3390/nu8060318
  • Anticancer : Cuminaldehyde
  • Antiproliferative : Cuminaldehyde
  • Chemopreventive : Cuminaldehyde
30
Perng DS, Tsai YH, Cherng J, Wang JS, Chou KS, Shih CW, Cherng JM(2016). Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. Drug Design, Development and Therapy. 10:141–153. DOI: 10.2147/DDDT.S93599
  • Anticancer : 2-methoxycinnamaldehyde
  • NF-kB-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-I-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-II-Inhibitor : 2-methoxycinnamaldehyde
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