SpiceCom: A database of phytochemicals in major spices

Ginger

Overview
Compounds
Activities
References
Crop: Ginger
Total No. of activities: 94
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1
Ajayi BO, Adedara IA, Farombi EO(2018). Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice. Human & Experimental Toxicology. January. DOI: 10.1177/0960327117751235
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
  • Antiulcer : 6-gingerol
  • NF-kB-Inhibitor : 6-gingerol
2
Alibakhshi T, Khodayar MJ, Khorsandi L, Rashno M, Zeidooni L(2018). Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomedicine & Pharmacotherapy. 105:225–232. DOI: 10.1016/j.biopha.2018.05.085
  • Nephroprotective : Gingerone
3
Annamalai G, Suresh K(2018). [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis. Biomedicine & Pharmacotherapy. 98:484-490. DOI: 10.1016/j.biopha.2017.12.009
  • Antiinflammatory : 6-shogaol
  • Antitumorigenic : 6-shogaol
  • NF-kB-Inhibitor : 6-shogaol
4
Cui Y, Shi Y, Bao Y, Wang S, Hua Q, Liu Y(2018). Zingerone attenuates diabetic nephropathy through inhibition of nicotinamide adenine dinucleotide phosphate oxidase 4. Biomedicine & Pharmacotherapy. 99:422-430. DOI: 10.1016/j.biopha.2018.01.051
  • Nephroprotective : Gingerone
5
Ezzat SM, Ezzat MI, Okba MM, Menze ET, Abdel-Naim AB(2018). The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. Journal of Ethnopharmacology. 214:113-123. DOI: 10.1016/j.jep.2017.12.019
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-paradol
  • Antiinflammatory : 6-shogaol
  • Antilipoxygenase : 6-gingerol
  • Antilipoxygenase : 6-shogaol
6
Kim CY, Seo Y, Lee C, Park GH, Jang JH(2018). Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice. Evidence-Based Complementary and Alternative Medicine. 2018:8941564. DOI: 10.1155/2018/8941564
  • Neuroprotective : 6-gingerol
7
Kotowski U, Kadletz L, Schneider S, Foki E, Schmid R, Seemann R3, Thurnher D, Heiduschka G(2018). 6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines. Phytotherapy research. 32(2):340-347. DOI: 10.1002/ptr.5982
  • Apoptosis inducer : 6-gingerol
  • Apoptosis inducer : 6-shogaol
8
Lee W, Hwang MH, Lee Y, Bae JS(2018). Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways. Chemico-Biological Interactions. 281:106-110. DOI: 10.1016/j.cbi.2017.12.031
  • Hepatoprotective : Gingerone
9
Luo Y, Chen X, Luo L, Zhang Q, Gao C, Zhuang X, Yuan S, Qiao T(2018). [6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction. Oncology Reports. March. DOI: 10.3892/or.2018.6292
  • Apoptosis inducer : 6-gingerol
10
Nedungadi D, Binoy A, Pandurangan N1, Pal S, Nair BG, Mishra N(2018). 6-Shogaol induces caspase-independent paraptosis in cancer cells via proteasomal inhibition. Experimental Cell Research. 364(2):243-251. DOI: 10.1016/j.yexcr.2018.02.018
  • Anticancer : 6-shogaol
  • paraptosis-inducer : 6-shogaol
11
Rehman MU, Rashid SM, Rasool S, Shakeel S, Ahmad B, Ahmad SB, Madkhali H, Ganaie MA, Majid S, Bhat SA(2018). Zingerone (4-(4-hydroxy-3-methylphenyl)butan-2-one) ameliorates renal function via controlling oxidative burst and inflammation in experimental diabetic nephropathy. Archives of Physiology and Biochemistry. :9-Jan. DOI: 10.1080/13813455.2018.1448422
  • antihyperglycemic : Gingerone
  • Antiinflammatory : Gingerone
  • Antioxidant : Gingerone
12
Si W, Chen YP, Zhang J, Chen ZY, Chung HY(2018). Antioxidant activities of ginger extract and its constituents toward lipids. Food Chemistry. 239:1117-1125. DOI: 10.1016/j.foodchem.2017.07.055
  • Antioxidant : 10-gingerol
  • Antioxidant : 6-gingerol
  • Antioxidant : 6-shogaol
  • Antioxidant : 8-gingerol
13
Wang S, Tian M, Yang R, Jing Y, Chen W, Wang J, Zheng X, Wang F(2018). 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE−/− Mice Exposed to Chronic Mild Stress. Cardiovascular Toxicology. :11-Jan. DOI: 10.1007/s12012-018-9452-4
  • Antiatherosclerotic : 6-gingerol
14
Bernard MM, McConnery JR, Hoskin DW(2017). [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Experimental and Molecular Pathology. 102(2):370-376. DOI: 10.1016/j.yexmp.2017.03.006
  • Anti-breast cancer : 10-gingerol
  • Anti-breast cancer : 6-gingerol
  • Anti-breast cancer : 8-gingerol
  • Apoptosis inducer : 10-gingerol
  • Cytotoxic : 10-gingerol
15
Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh, Fang-Rong Chang(2017). 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. International Journl of Molecular Sciences. 18(1). DOI: 10.3390/ijms18010168
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-shogaol
  • Antiobesity : 6-paradol
16
Cuya T, Baptista L, Celmar Costa França T(2017). A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease.. Journal of biomolecular structure & dynamics. :13-Jan. DOI: 10.1080/07391102.2017.1401004
  • Antiacetylcholinesterase : Gingerenone-a
17
Han Q, Yuan Q, Meng X, Huo J, Bao Y, Xie G(2017). 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-Y. Oncotarget. 8(26):42001-42006. DOI: 10.18632/oncotarget.16719
  • Antiinflammatory : 6-shogaol
18
Hitomi S, Ono K, Terawaki K, Matsumoto C, Mizuno K, Yamaguchi K, Imai R, Omiya Y, Hattori T, Kase Y, Inenaga K(2017). [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels . Pharmacological Research. 117:288-302. DOI: 10.1016/j.phrs.2016.12.026
  • Analgesic : 6-gingerol
  • Analgesic : 6-shogaol
19
Lee W, Ku SK, Kim MA, Bae JS(2017). Anti-factor Xa activities of zingerone with anti-platelet aggregation activity. Food and Chemical Toxicology. 105:186-193. DOI: 10.1016/j.fct.2017.04.012
  • Anticoagulant : Gingerone
  • Antifactor Xa : Gingerone
  • Antiplatelet : Gingerone
  • Antithrombic : Gingerone
20
Li TY, Chiang BH(2017). 6-shogaol induces autophagic cell death then triggered apoptosis in colorectal adenocarcinoma HT-29 cells. Biomedicine & Pharmacotherapy. 93:208-217. DOI: 10.1016/j.biopha.2017.06.038
  • Apoptosis inducer : 6-shogaol
  • Autophagy inducer : 6-shogaol
21
Liu CM, Kao CL, Tseng YT, Lo YC, Chen CY(2017). Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 22(9). DOI: 10.3390/molecules22091477
  • Antiproliferative : 10-gingerol
  • Antiproliferative : 10-shogaol
  • Antiproliferative : 6-gingerol
  • Antiproliferative : 6-shogaol
22
Martin ACBM, Fuzer AM, Becceneri AB, da Silva JA, Tomasin R, Denoyer D, Kim SH, McIntyre KA, Pearson HB, Yeo B, Nagpal A, Ling X, Selistre-de-Araújo HS, Vieira PC, Cominetti MR, Pouliot N(2017). [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. Oncotarget. 8(42):72260-72271. DOI: 10.18632/oncotarget.20139
  • Anticancer : 10-gingerol
  • Antitumor : 10-gingerol
  • Apoptosis inducer : 10-gingerol
23
Min G, Ku SK, Lee T, Bae JS(2017). Suppressive effects of zingerone on TGFBIp-mediated septic responses. Archives of Pharmacal Research. May. DOI: 10.1007/s12272-017-0919-9
  • Antiseptic : Gingerone
  • TGFBIp inhibitor : Gingerone
24
Samad MB, Mohsin MNAB, Razu BA, Hossain MT, Mahzabeen S, Unnoor N, Muna IA, Akhter F, Kabir AU, Hannan JMA(2017). [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice. BMC Complementary and Alternative Medicine. 17(1):395. DOI: 10.1186/s12906-017-1903-0
  • Insulinotropic : 6-gingerol
25
Sampath C, Rashid MR, Sang S, Ahmedna M(2017). Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway. Food Chemistry. 226:79-88. DOI: 10.1016/j.foodchem.2017.01.056
  • AntiAGE : 6-gingerol
  • Antidiabetic : 6-gingerol
  • antihyperglycemic : 6-gingerol
26
Seow SLS, Hong SL, Lee GS, Malek SNA, Sabaratnam V(2017). 6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells.. BMC complementary and alternative medicine. 17(1):334. DOI: 10.1186/s12906-017-1837-6
  • Neuritogenic : 6-shogaol
27
Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung MY, Kwon JY, Yang S, Kim JK, Park JHY, Lee KW(2017). Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Molecular nutrition & food research. 61(10). DOI: 10.1002/mnfr.201700139
  • antiadipogenic : Gingerenone-a
  • Antiatherosclerotic : Ar-turmerone
  • Antiobesity : Gingerenone-a
28
Wang Q, Wei Q, Yang Q, Cao X, Li Q1, Shi F, Tong SS, Feng C, Yu Q, Yu J, Xu X(2017). A novel formulation of [6]-gingerol: Proliposomes with enhanced oral bioavailability and antitumor effect.. International journal of pharmaceutics. 535(2-Jan):308-315. DOI: 10.1016/j.ijpharm.2017.11.006
  • Antitumor : 6-gingerol
  • Antitumor : 6-gingerol
29
Amri M, Touil-Boukoffa C(2016). In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol. Asian Pacific Journal of Tropical Medicine. 9(8):749-756. DOI: 10.1016/j.apjtm.2016.06.013
  • Antihydatic : 6-gingerol
  • Cytotoxic : 6-gingerol
  • Immunomodulatory : 6-gingerol
  • Larvicidal : 6-gingerol
30
Annamalai G, Kathiresan S, Kannappan N(2016). [6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells. Biomedicine & Pharmacotherapy. 82:226-236. DOI: 10.1016/j.biopha.2016.04.044
  • Anti-laryngeal cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Cytotoxic : 6-shogaol
31
Cheong KO, Shin DS, Bak J, Lee C, Kim KW, Je NK, Chung HY, Yoon S, Moon JO(2016). Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. Archives of Pharmacal Research. 39(2):279–291. DOI: 10.1007/s12272-015-0696-2
  • Antifibrotic : Gingerone
  • Antiinflammatory : Gingerone
  • Antioxidant : Gingerone
  • Hepatoprotective : Gingerone
  • NF-kB-Inhibitor : Gingerone
32
Joo JH, Hong SS, Cho YR, Seo DW(2016). 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncology Reports. 35(2):779-784. DOI: 10.3892/or.2015.4405
  • Antiinvasive : 10-gingerol
  • Antiproliferative : 10-gingerol
  • Antitumor : 10-gingerol
33
Kathiresan S, Govindhan A(2016). [6]-Shogaol, a Novel Chemopreventor in 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis. Phytotherapy research. 30(4):646–653. DOI: 10.1002/ptr.5574
  • Anti-oral cancer : 6-shogaol
  • Antioxidant : 6-shogaol
  • Antitumor : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Chemopreventive : 6-shogaol
34
Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, Iida M, Kumasaka MY, Yajima I, Goto Y, Ohgami N, Kato M, Takeda K(2016). Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.. The Journal of nutritional biochemistry. 27:112-22. DOI: 10.1016/j.jnutbio.2015.08.025
  • Antiallergic : 6-gingerol
35
Luettig J, Rosenthal R, Lee IM, Krug SM, Schulzke JD(2016). The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling. Molecular nutrition & food research. 60(12):2576-2586. DOI: 10.1002/mnfr.201600274
  • Barrier protective : 6-shogaol
  • NF-kB-Inhibitor : 6-shogaol
  • TNF-alpha-Inhibitor : 6-shogaol
36
Na JY, Song K, Lee JW, Kim S, Kwon J(2016). 6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer's disease via CysLT1R-mediated inhibition of cathepsin B. Biochemical and Biophysical Research Communications. 477(1):96-102. DOI: 10.1016/j.bbrc.2016.06.026
  • Anti-amyloidogenic : 6-shogaol
  • Antialzheimer's : 6-shogaol
  • Neuroprotective : 6-shogaol
37
Park G, Oh DS, Lee MG, Lee CE, Kim YU(2016). 6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf2 pathway. Toxicology and Applied Pharmacology. 310:51-59. DOI: 10.1016/j.taap.2016.08.019
  • Antiallergic : 6-shogaol
  • Antiinflammatory : 6-shogaol
  • Antioxidant : 6-shogaol
38
Sampath C, Zhu Y, Sang S, Ahmedna M(2016). Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells. Phytomedicine. 23(2):200-213. DOI: 10.1016/j.phymed.2015.12.013
  • AntiAGE : 6-gingerol
  • AntiAGE : 6-shogaol
  • Cytoprotective : 6-gingerol
  • Cytoprotective : 6-shogaol
39
Wang S, Sun X, Jiang L, Liu X, Chen M, Yao X, Sun Q, Yang G(2016). 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chemico-Biological Interactions. 256:249-56. DOI: 10.1016/j.cbi.2016.07.020
  • Antiapoptotic : 6-gingerol
  • Autophagy inducer : 6-gingerol
40
Ajayi BO, Adedara IA, Farombi EO(2015). Pharmacological Activity of 6-Gingerol in Dextran Sulphate Sodium-induced Ulcerative Colitis in BALB/c Mice. Phytotherapy research. 29(4):566-572. DOI: 10.1002/ptr.5286
  • Anticolitic : 6-gingerol
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
41
Bernard M, Furlong SJ, Power Coombs MR, Hoskin DW(2015). Differential Inhibition of T Lymphocyte Proliferation and Cytokine Synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-Gingerol. Phytotherapy research. 29(11):1707-1713. DOI: 10.1002/ptr.5414
  • Antiinflammatory : 10-gingerol
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 8-gingerol
42
Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW(2015). Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. The Journal of biological chemistry. 290(39):23553-23562. DOI: 10.1074/jbc.M115.662445
  • Anticancer : Gingerenone-a
  • Antitumor : Gingerenone-a
  • Apoptosis inducer : Gingerenone-a
43
Chunbo Li, Lin Zhou(2015). Inhibitory effect 6-gingerol on adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes. Toxicology in Vitro. 30(1):394-401. DOI: 10.1016/j.tiv.2015.09.023
  • antiadipogenic : 6-gingerol
44
Fan J, Yang X, Bi Z(2015). 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumor Biology. 36(2):1135-1141. DOI: 10.1007/s1327
  • Anticancer : 6-gingerol
  • Apoptosis inducer : 6-gingerol
45
Hsiang CY, Cheng HM, Lo HY, Li CC, Chou PC, Lee YC, Ho TY(2015). Ginger and Zingerone Ameliorate Lipopolysaccharide-Induced Acute Systemic Inflammation in Mice, Assessed by Nuclear Factor-κB Bioluminescent Imaging. Journal of agricultural and food chemistry. 63(26):6051-8. DOI: 10.1021/acs.jafc.5b01801
  • Antiinflammatory : Gingerone
46
Hsu YL, Hung JY, Tsai YM, Tsai EM, Huang MS, Hou MF, Kuo PL(2015). 6-Shogaol, an Active Constituent of Dietary Ginger, Impairs Cancer Development and Lung Metastasis by Inhibiting the Secretion of CC-Chemokine Ligand 2 (CCL2) in Tumor-Associated Dendritic Cells. Journal of agricultural and food chemistry. 63(6):1730-8. DOI: 10.1021/jf504934m
  • Anti-breast cancer : 6-shogaol
  • Anti-lung cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
47
Kim HS, Lee SH, Byun Y, Park HD(2015). 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Scientific reports. 5:8656. DOI: 10.1038/srep08656
  • Antibiofilm : 6-gingerol
48
Kim SM, Kim C, Bae H, Lee JH, Baek SH, Nam D, Chung WS, Shim BS, Lee SG, Kim SH, Sethi G, Ahn KS(2015). 6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways. Molecular Carcinogenesis. 54(10):1132-46. DOI: 10.1002/mc.22184
  • Anticancer : 6-shogaol
  • Antiproliferative : 6-shogaol
  • Antitumor : 6-shogaol
  • Apoptosis inducer : 6-shogaol
49
Liu R, Heiss EH, Sider N, Schinkovitz A, Gröblacher B, Guo D, Bucar F, Bauer R, Dirsch VM, Atanasov AG(2015). Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation. Molecular nutrition & food research. 59(5):843-852. DOI: 10.1002/mnfr.201400791
  • Antiproliferative : 6-shogaol
50
Pallashri Saha, Atul Katarkar, Bornita Das, Aritra Bhattacharyya & KeyaChaudhuri(2015). 6-Gingerol inhibits Vibrio cholerae-inducedproinflammatory cytokines in intestinal epithelialcells via modulation of NF-κB. Pharmaceutical Biology. 54(9). DOI: 10.3109/13880209.2015.1110598
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
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