SpiceCom: A database of phytochemicals in major spices

Ginger

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Compounds
Activities
References
Crop: Ginger
Total No. of activities: 94
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1
Abdel-Aziz H, Nahrstedt A, Petereit F, Windeck T, Ploch M, Verspohl EJ(2005). 5-HT3 Receptor Blocking Activity of Arylalkanes Isolated from the Rhizome of Zingiber officinale. Planta Medica. 71(7):609-616. DOI: 10.1055/s-2005-871265
  • Anti-5-HT : 10-gingerol
  • Anti-5-HT : 4-gingerol
  • Anti-5-HT : 6-dehydrogingerdione
  • Anti-5-HT : 6-gingerol
  • Anti-5-HT : 6-shogaol
  • Anti-5-HT : 8-gingerol
  • Anti-5-HT : 8-shogaol
2
Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ(2006). Mode of action of gingerols and shogaols on 5-HT3 receptors: Binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. European Journal of Pharmacology. 530(2-Jan):136-143. DOI: 10.1016/j.ejphar.2005.10.049
  • Anticholinergic : 10-gingerol
  • Anticholinergic : 6-gingerol
  • Anticholinergic : 6-shogaol
  • Anticholinergic : 8-gingerol
  • Antiemetic : 10-gingerol
  • Antiemetic : 6-gingerol
  • Antiemetic : 6-shogaol
  • Antiemetic : 8-gingerol
  • Antineurokininergic : 10-gingerol
  • Antineurokininergic : 6-gingerol
  • Antineurokininergic : 6-shogaol
  • Antineurokininergic : 8-gingerol
3
Agarwal M, Walia S, Dhingra S, Khambay BP(2001). Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes. Pest Management Science. 57(3):289-300. DOI: 10.1002/ps.263
  • Antifeedant : 6-gingerol
  • Antifungal : Dehydrozingerone
  • Insect growth regulatory : [6]-dehydroshogaol
4
Ajayi BO, Adedara IA, Farombi EO(2018). Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice. Human & Experimental Toxicology. January. DOI: 10.1177/0960327117751235
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
  • Antiulcer : 6-gingerol
  • NF-kB-Inhibitor : 6-gingerol
5
Ajayi BO, Adedara IA, Farombi EO(2015). Pharmacological Activity of 6-Gingerol in Dextran Sulphate Sodium-induced Ulcerative Colitis in BALB/c Mice. Phytotherapy research. 29(4):566-572. DOI: 10.1002/ptr.5286
  • Anticolitic : 6-gingerol
  • Antiinflammatory : 6-gingerol
  • Antioxidant : 6-gingerol
6
Alibakhshi T, Khodayar MJ, Khorsandi L, Rashno M, Zeidooni L(2018). Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomedicine & Pharmacotherapy. 105:225–232. DOI: 10.1016/j.biopha.2018.05.085
  • Nephroprotective : Gingerone
7
Amri M, Touil-Boukoffa C(2016). In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol. Asian Pacific Journal of Tropical Medicine. 9(8):749-756. DOI: 10.1016/j.apjtm.2016.06.013
  • Antihydatic : 6-gingerol
  • Cytotoxic : 6-gingerol
  • Immunomodulatory : 6-gingerol
  • Larvicidal : 6-gingerol
8
Annamalai G, Kathiresan S, Kannappan N(2016). [6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells. Biomedicine & Pharmacotherapy. 82:226-236. DOI: 10.1016/j.biopha.2016.04.044
  • Anti-laryngeal cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Cytotoxic : 6-shogaol
9
Annamalai G, Suresh K(2018). [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis. Biomedicine & Pharmacotherapy. 98:484-490. DOI: 10.1016/j.biopha.2017.12.009
  • Antiinflammatory : 6-shogaol
  • Antitumorigenic : 6-shogaol
  • NF-kB-Inhibitor : 6-shogaol
10
Bernard M, Furlong SJ, Power Coombs MR, Hoskin DW(2015). Differential Inhibition of T Lymphocyte Proliferation and Cytokine Synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-Gingerol. Phytotherapy research. 29(11):1707-1713. DOI: 10.1002/ptr.5414
  • Antiinflammatory : 10-gingerol
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 8-gingerol
11
Bernard MM, McConnery JR, Hoskin DW(2017). [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Experimental and Molecular Pathology. 102(2):370-376. DOI: 10.1016/j.yexmp.2017.03.006
  • Anti-breast cancer : 10-gingerol
  • Anti-breast cancer : 6-gingerol
  • Anti-breast cancer : 8-gingerol
  • Apoptosis inducer : 10-gingerol
  • Cytotoxic : 10-gingerol
12
Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW(2015). Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. The Journal of biological chemistry. 290(39):23553-23562. DOI: 10.1074/jbc.M115.662445
  • Anticancer : Gingerenone-a
  • Antitumor : Gingerenone-a
  • Apoptosis inducer : Gingerenone-a
13
Chakraborty D, Bishayee K, Ghosh S, Biswas R, Mandal SK, Khuda-Bukhsh AR(2012). [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: Drug–DNA interaction and expression of certain signal genes in HeLa cells. European Journal of Pharmacology. 694(3-Jan):20-29. DOI: 10.1016/j.ejphar.2012.08.001
  • Apoptosis inducer : 6-gingerol
  • Autophagy inducer : 6-gingerol
14
Chakraborty D, Mukherjee A, Sikdar S, Paul A, Ghosh S, Khuda-Bukhsh AR(2012). [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicology Letters. 210(1):34-43. DOI: 10.1016/j.toxlet.2012.01.002
  • antihyperglycemic : 6-gingerol
15
Chen CY, Cheng KC, Chang AY, Lin YT, Hseu YC, Wang HM(2012). 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 13(2):1762-1777. DOI: 10.3390/ijms13021762
  • Antioxidant : 10-shogaol
16
Chen CY, Liu TZ, Liu YW, Tseng WC, Liu RH, Lu FJ, Lin YS, Kuo SH, Chen CH(2007). 6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an Oxidative Stress-Mediated Caspase-Dependent Mechanism. Journal of Agricultural and Food Chemistry. 55(3):948-954. DOI: 10.1021/jf0624594
  • Apoptosis inducer : 6-shogaol
17
Chen JC, Huang LJ, Wu SL, Kuo SC, Ho TY, Hsiang CY(2007). Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice. Journal of Agricultural and Food Chemistry. 55(21):8390-8397. DOI: 10.1021/jf071460f
  • Antidiarrheal : Gingerone
18
Cheong KO, Shin DS, Bak J, Lee C, Kim KW, Je NK, Chung HY, Yoon S, Moon JO(2016). Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. Archives of Pharmacal Research. 39(2):279–291. DOI: 10.1007/s12272-015-0696-2
  • Antifibrotic : Gingerone
  • Antiinflammatory : Gingerone
  • Antioxidant : Gingerone
  • Hepatoprotective : Gingerone
  • NF-kB-Inhibitor : Gingerone
19
Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh, Fang-Rong Chang(2017). 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. International Journl of Molecular Sciences. 18(1). DOI: 10.3390/ijms18010168
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-paradol
  • antihyperglycemic : 6-shogaol
  • Antiobesity : 6-paradol
20
Chunbo Li, Lin Zhou(2015). Inhibitory effect 6-gingerol on adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes. Toxicology in Vitro. 30(1):394-401. DOI: 10.1016/j.tiv.2015.09.023
  • antiadipogenic : 6-gingerol
21
Cui Y, Shi Y, Bao Y, Wang S, Hua Q, Liu Y(2018). Zingerone attenuates diabetic nephropathy through inhibition of nicotinamide adenine dinucleotide phosphate oxidase 4. Biomedicine & Pharmacotherapy. 99:422-430. DOI: 10.1016/j.biopha.2018.01.051
  • Nephroprotective : Gingerone
22
Cuya T, Baptista L, Celmar Costa França T(2017). A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease.. Journal of biomolecular structure & dynamics. :13-Jan. DOI: 10.1080/07391102.2017.1401004
  • Antiacetylcholinesterase : Gingerenone-a
23
Denyer CV, Jackson P, Loakes DM, Ellis MR, Young DA(1994). Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale). Journal of Natural Products. 57(5):658-652. DOI: 10.1021/np50107a017
  • Antirhinoviral : Sesquiphellandrene
24
Dugasani S1, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN(2010). Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of Ethnopharmacology. 127(2):515-520. DOI: 10.1016/j.jep.2009.10.004
  • Antiinflammatory : 10-gingerol
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-shogaol
  • Antiinflammatory : 8-gingerol
25
El-Bakly WM, Louka ML, El-Halawany AM, Schaalan MF(2012). 6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation. Cancer Chemotherapy and Pharmacology. 70(6):833-841. DOI: 10.1007/s00280-012-1975-y
  • Cardioprotective : 6-gingerol
26
Etoh H, Kondoh T, Noda R, Singh IP, Sekiwa Y, Morimitsu K, Kubota K(2002). Shogaols from Zingiber officinale as Promising Antifouling Agents. Bioscience, Biotechnology, and Biochemistry . 66(8):1748-1750. DOI: 10.1271/bbb.66.1748
  • Antifouling : 8-shogaol
27
Ezzat SM, Ezzat MI, Okba MM, Menze ET, Abdel-Naim AB(2018). The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. Journal of Ethnopharmacology. 214:113-123. DOI: 10.1016/j.jep.2017.12.019
  • Antiinflammatory : 6-gingerol
  • Antiinflammatory : 6-paradol
  • Antiinflammatory : 6-shogaol
  • Antilipoxygenase : 6-gingerol
  • Antilipoxygenase : 6-shogaol
28
Fan J, Yang X, Bi Z(2015). 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumor Biology. 36(2):1135-1141. DOI: 10.1007/s1327
  • Anticancer : 6-gingerol
  • Apoptosis inducer : 6-gingerol
29
Ficker C, Smith ML, Akpagana K, Gbeassor M, Zhang J, Durst T, Assabgui R, Arnason JT(2003). Bioassay-guided isolation and identification of antifungal compounds from ginger. Phytotherapy Research. 17(8):897-902. DOI: 10.1002/ptr.1335
  • Antifungal : 10-gingerol
  • Antifungal : 6-gingerdiol
  • Antifungal : 6-gingerol
  • Antifungal : 8-gingerol
30
Ghayur MN, Gilani AH, Afridi MB, Houghton PJ(2005). Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascular Pharmacology. 43(4):234-241. DOI: 10.1016/j.vph.2005.07.003
  • Vasodilator : 10-gingerol
  • Vasodilator : 6-gingerol
  • Vasodilator : 6-shogaol
  • Vasodilator : 8-gingerol
31
Goto C, Kasuya S, Koga K, Ohtomo H, Kagei N(1990). Lethal efficacy of extract fromZingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol inAnisakis larvae in vitro. Parasitology Research. 76(8):653-656. DOI: 10.1007/BF00931082
  • Larvicidal : 6-gingerol
  • Larvicidal : 6-shogaol
32
Guh JH, Ko FN, Jong TT, Teng CM(1995). Antiplatelet Effect of Gingerol Isolated from Zingiber officinale. Journal of Pharmacy and Pharmacology. 47(4):329-332. DOI: 10.1111/j.2042-7158.1995.tb05804.x
  • Antiplatelet : 6-gingerol
33
Ha SK, Moon E, Ju MS, Kim DH, Ryu JH, Oh MS, Kim SY(2012). 6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection. Neuropharmacology. 63(2):211-223. DOI: 10.1016/j.neuropharm.2012.03.016
  • Anti-neuroinflammatory : 6-shogaol
  • Neuroprotective : 6-shogaol
34
Han Q, Yuan Q, Meng X, Huo J, Bao Y, Xie G(2017). 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-Y. Oncotarget. 8(26):42001-42006. DOI: 10.18632/oncotarget.16719
  • Antiinflammatory : 6-shogaol
35
Hitomi S, Ono K, Terawaki K, Matsumoto C, Mizuno K, Yamaguchi K, Imai R, Omiya Y, Hattori T, Kase Y, Inenaga K(2017). [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels . Pharmacological Research. 117:288-302. DOI: 10.1016/j.phrs.2016.12.026
  • Analgesic : 6-gingerol
  • Analgesic : 6-shogaol
36
Hsiang CY, Cheng HM, Lo HY, Li CC, Chou PC, Lee YC, Ho TY(2015). Ginger and Zingerone Ameliorate Lipopolysaccharide-Induced Acute Systemic Inflammation in Mice, Assessed by Nuclear Factor-κB Bioluminescent Imaging. Journal of agricultural and food chemistry. 63(26):6051-8. DOI: 10.1021/acs.jafc.5b01801
  • Antiinflammatory : Gingerone
37
Hsu YL, Chen CY, Hou MF, Tsai EM, Jong YJ, Hung CH, Kuo PL(2010). 6‐Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c‐Jun N‐terminal kinase pathways in human breast cancer cells. Molecular Nutrition & Food Research. 54(9):1307-17. DOI: 10.1002/mnfr.200900125
  • Anti-breast cancer : 6-dehydrogingerdione
  • Apoptosis inducer : 6-dehydrogingerdione
38
Hsu YL, Hung JY, Tsai YM, Tsai EM, Huang MS, Hou MF, Kuo PL(2015). 6-Shogaol, an Active Constituent of Dietary Ginger, Impairs Cancer Development and Lung Metastasis by Inhibiting the Secretion of CC-Chemokine Ligand 2 (CCL2) in Tumor-Associated Dendritic Cells. Journal of agricultural and food chemistry. 63(6):1730-8. DOI: 10.1021/jf504934m
  • Anti-breast cancer : 6-shogaol
  • Anti-lung cancer : 6-shogaol
  • Apoptosis inducer : 6-shogaol
39
Hu R, Zhou P, Peng YB, Xu X, Ma J, Liu Q, Zhang L, Wen XD, Qi LW, Gao N, Li P(2012). 6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells and Exhibits Anti-Tumor Activity In Vivo through Endoplasmic Reticulum Stress. PLOS ONE. 7(6):e39664. DOI: 10.1371/journal.pone.0039664
  • Antitumor : 6-shogaol
  • Apoptosis inducer : 6-shogaol
40
Huang HC, Chang SJ, Wu CY, Ke HJ, Chang TM(2014). [6]-Shogaol inhibits α-MSH-induced melanogenesis through the acceleration of ERK and PI3K/Akt-mediated MITF degradation. BioMed Research International. 2014:842569. DOI: 10.1155/2014/842569
  • Antimelanogenic : 6-shogaol
  • Tyrosinase-Inhibitor : 6-shogaol
41
Huang HC, Chiu SH, Chang TM(2011). Inhibitory Effect of [6]-Gingerol on Melanogenesis in B16F10 Melanoma Cells and a Possible Mechanism of Action. Bioscience, Biotechnology, and Biochemistry. 75(6):1067-72. DOI: 10.1271/bbb.100851
  • Antimelanogenic : 6-gingerol
  • Tyrosinase-Inhibitor : 6-gingerol
42
Huang QR1, Iwamoto M, Aoki S, Tanaka N, Tajima K, Yamahara J, Takaishi Y, Yoshida M, Tomimatsu T, Tamai Y(1991). Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger. Chemical & pharmaceutical bulletin. 39(2):397-9. DOI: 10.1248/cpb.39.397
  • Anti-5-HT : Galanolactone
43
Hung JY, Hsu YL, Li CT, Ko YC, Ni WC, Huang MS, Kuo PL(2009). 6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. Journal of Agricultural and Food Chemistry. 57(20):9809-16. DOI: 10.1021/jf902315e
  • Anti-lung cancer : 6-shogaol
  • Autophagy inducer : 6-shogaol
  • Chemopreventive : 6-shogaol
44
Iwami M, Shiina T, Hirayama H, Shima T, Takewaki T, Shimizu Y(2011). Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats. Journal of Natural Medicines. 65(1):89-984. DOI: 10.1007/s11418-010-0463-0
  • Antidiarrheal : Gingerone
45
Jeong CH, Bode AM, Pugliese A, Cho YY, Kim HG, Shim JH, Jeon YJ, Li H, Jiang H, Dong Z(2009). [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Research. 69(13):5584-5591. DOI: 10.1158/0008-5472.CAN-09-0491
  • Anti-colon cancer : 6-gingerol
46
Jin Z, Lee G, Kim S, Park CS, Park YS, Jin YH(2014). Ginger and Its Pungent Constituents Non-Competitively Inhibit Serotonin Currents on Visceral Afferent Neurons. The Korean Journal of Physiology & Pharmacology. 18(2):149-53. DOI: 10.4196/kjpp.2014.18.2.149
  • Anti-5-HT : 6-gingerol
  • Anti-5-HT : 6-shogaol
  • Anti-5-HT : Gingerone
  • Antiemetic : 6-gingerol
  • Antiemetic : 6-shogaol
  • Antiemetic : Gingerone
47
Joo JH, Hong SS, Cho YR, Seo DW(2016). 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncology Reports. 35(2):779-784. DOI: 10.3892/or.2015.4405
  • Antiinvasive : 10-gingerol
  • Antiproliferative : 10-gingerol
  • Antitumor : 10-gingerol
48
Ju SA, Park SM, Lee YS, Bae JH, Yu R, An WG, Suh JH, Kim BS(2012). Administration of 6‐gingerol greatly enhances the number of tumor‐infiltrating lymphocytes in murine tumors. International Journal of Cancer. 130(11):2618-2628. DOI: 10.1002/ijc.26316
  • Antitumor : 6-gingerol
49
Kathiresan S, Govindhan A(2016). [6]-Shogaol, a Novel Chemopreventor in 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis. Phytotherapy research. 30(4):646–653. DOI: 10.1002/ptr.5574
  • Anti-oral cancer : 6-shogaol
  • Antioxidant : 6-shogaol
  • Antitumor : 6-shogaol
  • Apoptosis inducer : 6-shogaol
  • Chemopreventive : 6-shogaol
50
Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, Iida M, Kumasaka MY, Yajima I, Goto Y, Ohgami N, Kato M, Takeda K(2016). Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.. The Journal of nutritional biochemistry. 27:112-22. DOI: 10.1016/j.jnutbio.2015.08.025
  • Antiallergic : 6-gingerol
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