SpiceCom: A database of phytochemicals in major spices

Cinnamon

Overview
Compounds
Activities
References
Crop: Cinnamon
Total No. of activities: 46
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1
Yoo W, Yoo D, Hong E, Jung E, Go Y, Singh SVB, Khang G, Lee D3(2018). Acid-activatable oxidative stress-inducing polysaccharide nanoparticles for anticancer therapy.. Journal of controlled release : official journal of the Controlled Release Society. 269:235-244. DOI: 10.1016/j.jconrel.2017.11.023
  • Anticancer : Cinnamaldehyde
2
Yue Wang, Yi Zhang, Yan-qin Shi, Xian-hua Pan, Yan-hua Lu, Ping Cao(2018). Antibacterial effects of cinnamon (Cinnamomum zeylanicum) bark essential oil on Porphyromonas gingivalis. Microbial Pathogenesis. 116:26-32. DOI: 10.1016/j.micpath.2018.01.009
  • Antibacterial : Cinnamaldehyde
  • Antibiofilm : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
3
Hosni AA, Abdel-Moneim AA, Abdel-Reheim ES, Mohamed SM, Helmy H(2017). Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARγ, proinflammatory cytokines and oxidative stress.. Biomedicine & Pharmacotherapy. 88:52-60. DOI: 10.1016/j.biopha.2017.01.054
  • Hypoglycemic : Cinnamaldehyde
4
Monteiro IN, Monteiro ODS, Costa-Junior LM, da Silva Lima A, Andrade EHA, Maia JGS, Mouchrek Filho VE.(2017). Chemical composition and acaricide activity of an essential oil from a rare chemotype of Cinnamomum verum Presl on Rhipicephalus microplus (Acari: Ixodidae).. Vet Parasitol.. 238:00:00(-):54-57. DOI: 10.1016/j.vetpar.2017.03.016
  • Acaricide : Benzyl-benzoate
  • Acaricide : Eugenol
5
Sharma UK, Sharma AK, Gupta A, Kumar R, Pandey A, Pandey AK(2017). Pharmacological activities of cinnamaldehyde and eugenol: antioxidant, cytotoxic and anti-leishmanial studies.. Cellular and molecular biology (Noisy-le-Grand, France). 63(6):73-78. DOI: 10.14715/cmb/2017.63.6.15
  • Antileishmanial : Cinnamaldehyde
  • Antileishmanial : Eugenol
  • Antioxidant : Cinnamaldehyde
  • Antioxidant : Eugenol
  • Cytotoxic : Cinnamaldehyde
  • Cytotoxic : Eugenol
6
AkshayJawalea, Ashok Kumar Datusaliaa, Mahendra Bishnoi, Shyam S.Sharma(2016). Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde. Phytomedicine. 23(9):923-930. DOI: 10.1016/j.phymed.2016.04.008
  • AChE-Inhibitor : Cinnamaldehyde
7
Connell BJ, Chang SY, Prakash E, Yousfi R, Mohan V, Posch W, Wilflingseder D, Moog C, Kodama EN7, Clayette P, Lortat-Jacob H(2016). A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.. PloS one. 11(10). DOI: 10.1371/journal.pone.0165386
  • AntiHIV : Ind02-trimer
8
Deletre E, Chandre F, Barkman B, Menut C, Martin T(2016). Naturally occurring bioactive compounds from four repellent essential oils against Bemisia tabaci whiteflies. Pest management science. 72(1):179-89. DOI: 10.1002/ps.3987
  • Repellent : Cinnamaldehyde
9
Imad Hadi Hameed, Huda Jasim Altameme, Ghaidaa Jihadi Mohammed(2016). Evaluation of Antifungal and Antibacterial Activity and Analysis of Bioactive Phytochemical Compounds of Cinnamomum Zeylanicum (Cinnamon Bark) using Gas Chromatography-Mass Spectrometry. Oriental Journal of Chemistry. 32(4):1769-1788. DOI: 10.13005/ojc/320406
  • Antimicrobial : Cinnamaldehyde
10
Kuen-daw Tsai, Yi-Heng Liu, Ta-Wei Chen, Shu-Mei Yang, Ho-Yiu Wong, Jonathan Cherng, Kuo-Shen Chou, Jaw-Ming Cherng(2016). Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells. Nutrients. 8(6). DOI: 10.3390/nu8060318
  • Anticancer : Cuminaldehyde
  • Antiproliferative : Cuminaldehyde
  • Chemopreventive : Cuminaldehyde
11
Mendes SJ, Sousa FI, Pereira DM, Ferro TA, Pereira IC, Silva BL, Pinheiro AJ, Mouchrek AQ, Monteiro-Neto V, Costa SK, Nascimento JL, Grisotto MA, da Costa R, Fernandes ES(2016). Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms. International Immunopharmacology. 34:60-70. DOI: 10.1016/j.intimp.2016.02.012
  • Immunomodulatory : Cinnamaldehyde
12
Perng DS, Tsai YH, Cherng J, Wang JS, Chou KS, Shih CW, Cherng JM(2016). Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. Drug Design, Development and Therapy. 10:141–153. DOI: 10.2147/DDDT.S93599
  • Anticancer : 2-methoxycinnamaldehyde
  • NF-kB-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-I-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-II-Inhibitor : 2-methoxycinnamaldehyde
13
Wong HY, Tsai KD1, Liu YH, Yang SM1,, Chen TW, Cherng J, Chou KS, Chang CM, Yao BT, Cherng JM(2016). Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytotherapy research : PTR. 30(2):331-40. DOI: 10.1002/ptr.5536
  • Anticancer : 2-methoxycinnamaldehyde
  • Antiproliferative : 2-methoxycinnamaldehyde
  • Chemopreventive : 2-methoxycinnamaldehyde
  • NF-kB-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-I-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-II-Inhibitor : 2-methoxycinnamaldehyde
14
Deletre E, Chandre F, Williams L, Duménil C, Menut C, Martin T(2015). Electrophysiological and behavioral characterization of bioactive compounds of the Thymus vulgaris, Cymbopogon winterianus, Cuminum cyminum and Cinnamomum zeylanicum essential oils against Anopheles gambiae and prospects for their use as bednet treatments. Parasites & vectors. 8:316. DOI: 10.1186/s13071-015-0934-y
  • Repellent : Cinnamaldehyde
15
Gunawardena D1, Karunaweera N, Lee S, van Der Kooy F, Harman DG, Raju R, Bennett L, Gyengesi E, Sucher NJ, Münch G(2015). Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - Identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds. Food & Function. 6(3). DOI: 10.1039/c4fo00680a
  • Antiinflammatory : 2-methoxycinnamaldehyde
  • Antiinflammatory : Cinnamaldehyde
16
Hagenlocher Y, Kiessling K, Schäffer M, Bischoff SC, Lorentz A(2015). Cinnamaldehyde is the main mediator of cinnamon extract in mast cell inhibition.. European journal of nutrition. 54(8):1297-309. DOI: 10.1007/s00394-014-0810-0
  • Antiallergic : Cinnamaldehyde
17
Homa M, Fekete IP, Böszörményi A, Singh YR, Selvam KP, Shobana CS, Manikandan P6, Kredics L, Vágvölgyi C, Galgóczy L(2015). Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates. Planta Medica. 81(14):1277-84. DOI: 10.1055/s-0035-1546272
  • Antifungal : Cinnamaldehyde
18
Kot B, Wicha J, Piechota M, Wolska K, Gruzewska A(2015). Antibiofilm activity of trans-cinnamaldehyde, p-coumaric, and ferulic acids on uropathogenic Escherichia coli.. Turkish journal of medical sciences. 45(4):919-24. DOI: 10.3906/sag-1406-112
  • Antibiofilm : Cinnamaldehyde
19
Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, Zhang DD, Wondrak GT(2015). Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prevention Research. 8(5):444-54. DOI: 10.1158/1940-6207.CAPR-14-0359
  • Anti-colon cancer : Cinnamaldehyde
  • Chemopreventive : Cinnamaldehyde
  • Nrf2 inducer : Cinnamaldehyde
20
Williams AR, Ramsay A, Hansen TV, Ropiak HM, Mejer H, Nejsum P, Mueller-Harvey I, Thamsborg SM(2015). Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum). Scientific reports. 5:14791. DOI: 10.1038/srep14791
  • Anthelmintic : Cinnamaldehyde
21
Yong-Guy Kim, Jin-Hyung Lee, Soon-Il Kim, Kwang-Hyun Baek, Jintae Lee(2015). Cinnamon bark oil and its components inhibit biofilm formation and toxin production. International Journal of Food Microbiology. 195:30-39. DOI: 10.1016/j.ijfoodmicro.2014.11.028
  • Antibiofilm : Cinnamaldehyde
  • Antibiofilm : Eugenol
  • Antihemolytic : Cinnamaldehyde
  • Antihemolytic : Eugenol
22
Fraňková A1, Marounek M, Mozrová V, Weber J, Klouček P, Lukešová D(2014). Antibacterial activities of plant-derived compounds and essential oils toward Cronobacter sakazakii and Cronobacter malonaticus.. Foodborne Pathogens and Disease. 11(10):795-7. DOI: 10.1089/fpd.2014.1737
  • Antibacterial : Cinnamaldehyde
23
Muthenna P, Raghu G1, Kumar PA, Surekha MV, Reddy GB(2014). Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chemico-Biological Interactions. 222:68-76. DOI: 10.1016/j.cbi.2014.08.013
  • AntiAGE : Procyanidin b2
24
Tina Sartorius, Andreas Peter, Nadja Schulz, Andrea Drescher, Ina Bergheim, Jürgen Machann, Fritz Schick, Dorothea Siegel-Axel, Annette Schürmann, Cora Weigert, Hans-Ulrich Häring, Anita M. Hennige(2014). Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity. PLOS ONE. 9(3). DOI: 10.1371/journal.pone.0092358
  • Antidiabetic : Eugenol
25
Abhinav Upadhyay, Indu Upadhyaya, Anup Kollanoor-Johny, Kumar Venkitanarayanan(2013). Antibiofilm effect of plant derived antimicrobials on Listeria monocytogenes. Food Microbiology. 36(1):79-89. DOI: 10.1016/j.fm.2013.04.010
  • Antibiofilm : Cinnamaldehyde
26
El-Sayed el-SM, Abd El-Raouf OM, Fawzy HM, Manie MF(2013). Comparative study of the possible protective effects of cinnamic acid and cinnamaldehyde on cisplatin-induced nephrotoxicity in rats.. Journal of biochemical and molecular toxicology. 27(12):508-514. DOI: 10.1002/jbt.21515
  • Nephroprotective : Cinnamaldehyde
  • Nephroprotective : Cinnamic-acid
27
Ho SC, Chang KS, Chang PW(2013). Inhibition of neuroinflammation by cinnamon and its main components. Food Chemistry. 138(4):2275-2282. DOI: 10.1016/j.foodchem.2012.12.020
  • Anti-neuroinflammatory : Cinnamaldehyde
28
Muthenna P, Raghu G, Akileshwari C, Sinha SN, Suryanarayana P, Reddy GB(2013). Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: Delay of diabetic cataract in rats. IUBMB life. 65(11):941-950. DOI: 10.1002/iub.1214
  • AntiAGE : Procyanidin b2
  • Antiglycating : Procyanidin b2
29
Naveed R, Hussain I, Tawab A, Tariq M, Rahman M, Hameed S, Mahmood MS, Siddique AB, Iqbal M(2013). Antimicrobial activity of the bioactive components of essential oils from Pakistani spices against Salmonella and other multi-drug resistant bacteria. BMC Complementary and Alternative Medicine. 13(265). DOI: 10.1186/1472-6882-13-265
  • Antimicrobial : Cinnamaldehyde
30
Takasao N, Tsuji-Naito K, Ishikura S, Tamura A, Akagawa M(2012). Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts.. Journal of agricultural and food chemistry. 60(5):1193-200. DOI: 10.1021/jf2043357
  • Antiaging : Cinnamaldehyde
31
Amalaradjou MA, Venkitanarayanan K(2011). Proteomic Analysis of the Mode of Antibacterial Action of Trans-Cinnamaldehyde Against Cronobacter sakazakii 415. Foodborne Pathogens and Disease. 8(10):1095-102. DOI: 10.1089/fpd.2011.0841
  • Antibacterial : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
32
Amalaradjou MA, Venkitanarayanan K(2011). Effect of trans-Cinnamaldehyde on Inhibition and Inactivation of Cronobacter sakazakii Biofilm on Abiotic Surfaces. Journal of Food Protection. 74(2):200-208. DOI: 10.4315/0362-028X.JFP-10-296
  • Antibiofilm : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
33
Hussain A, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA and Sharma C.(2011). Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells.. Cancer Biother Radiopharm.. 26(5):519-27. DOI: 10.1089/cbr.2010.0925
  • Analgesic : Eugenol
  • Anti-cervical cancer : Eugenol
  • Anticarcinogenic : Eugenol
  • Antiinflammatory : Eugenol
34
Mohd Sajjad AhmadKhan, IqbalAhmad(2011). In vitro antifungal, anti-elastase and anti-keratinase activity of essential oils of Cinnamomum-, Syzygium- and Cymbopogon-species against Aspergillus fumigatus and Trichophyton rubrum. Phytomedicine. 19(1):48-55. DOI: 10.1016/j.phymed.2011.07.005
  • Antielastase : Cinnamaldehyde
  • Antifungal : Cinnamaldehyde
  • Antikeratinase : Cinnamaldehyde
35
Anand P, Murali KY, Tandon V, Murthy PS, Chandra R(2010). Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats.. Chemico-biological interactions. 186(1):72-81. DOI: 10.1016/j.cbi.2010.03.044
  • Antidiabetic : Cinnamaldehyde
  • Insulinotropic : Cinnamaldehyde
36
Mary Anne Roshni, Amalaradjou Amoolya Narayanan, Sangeetha Ananda Baskaran, Kumar Venkitanarayanan(2010). Antibiofilm Effect of Trans-Cinnamaldehyde on Uropathogenic Escherichia coli. The Journal of Urology. 1(184):358-363. DOI: 10.1016/j.juro.2010.03.006
  • Antibiofilm : Cinnamaldehyde
37
Amalaradjou MA, Hoagland TA, Venkitanarayanan K(2009). Inactivation of Enterobacter sakazakii in reconstituted infant formula by trans-cinnamaldehyde. International Journal of Food Microbiology. 129(2):146-149. DOI: 10.1016/j.ijfoodmicro.2008.11.016
  • Antibacterial : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
38
Cabello CM, Bair WB III, Lamore SD, Ley S, Bause AS, Azimian S, Wondrak GT(2009). The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radical Biology and Medicine. 46(2):220-231. DOI: 10.1016/j.freeradbiomed.2008.10.025
  • Anticancer : Cinnamaldehyde
  • Antimelanoma : Cinnamaldehyde
  • Antiproliferative : Cinnamaldehyde
  • Antitumor : Cinnamaldehyde
  • NF-kB-Inhibitor : Cinnamaldehyde
39
Ibrahim bin Jantan, Bushra Abdul Karim Moharam, Jacintha Santhanam, Jamia Azdina Jamal(2008). Correlation Between Chemical Composition and Antifungal Activity of the Essential Oils of Eight Cinnamomum. Species. Pharmaceutical Biology. 46(6):406-412. DOI: 10.1080/13880200802055859
  • Antifungal : Cinnamaldehyde
  • Antifungal : Eugenol
40
KentaroTsuji-Naito(2008). Aldehydic components of Cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation. Bioorganic & Medicinal Chemistry. 16(20):9176-9183. DOI: 10.1016/j.bmc.2008.09.036
  • Osteoclastogenesis inbitor : 2-methoxycinnamaldehyde
  • Osteoclastogenesis inbitor : Cinnamaldehyde
41
Liesel Brenda Gende, Ignazio Floris, Rosalia Fritz, Martin Javier Eguaras(2008). Antimicrobial activity of cinnamon(Cinnamomum zeylanicum) essential oil and its main components against Paenibacillus larvae from Argentine. Bulletin of Insectology. 61(1):4-Jan. DOI: NoDOI1
  • Antibacterial : Cinnamaldehyde
  • Antibacterial : Eugenol
  • Antimicrobial : Cinnamaldehyde
  • Antimicrobial : Eugenol
42
Sen-SungCheng, Ju-YunLiu, Ed-HaunChang, Shang-TzenChang(2008). Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi. Bioresource Technology. 99(11):5145-5149. DOI: 10.1016/j.biortech.2007.09.013
  • Antifungal : Cinnamaldehyde
43
Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, Lee JY(2008). Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochemical pharmacology. 75(2):494-502. DOI: 10.1016/j.bcp.2007.08.033
  • Antiinflammatory : Cinnamaldehyde
44
Kim DH, Kim CH, Kim MS, Kim JY, Jung KJ, Chung JH, An WG, Lee JW, Yu BP, Chung HY(2007). Suppression of age-related inflammatory NF-κB activation by cinnamaldehyde. Biogerontology. 8(5):545-554. DOI: 10.1007/s10522-007-9098-2
  • Antiaging : Cinnamaldehyde
  • Antiinflammatory : Cinnamaldehyde
  • NF-kB-Inhibitor : Cinnamaldehyde
45
Marongiu B, Piras A, Porcedda S, Tuveri E, Sanjust E, Meli M, Sollai F, Zucca P, Rescigno A(2007). Supercritical CO2 extract of Cinnamomum zeylanicum: chemical characterization and antityrosinase activity.. Journal of agricultural and food chemistry. 55(24). DOI: 10.1021/jf071938f
  • Antityrosinase : Cinnamaldehyde
  • Antityrosinase : Eugenol
46
Subash Babu P, Prabuseenivasan S, Ignacimuthu S(2007). Cinnamaldehyde—A potential antidiabetic agent. Phytomedicine. 14(1):15-22. DOI: 10.1016/j.phymed.2006.11.005
  • Antidiabetic : Cinnamaldehyde
  • antihyperglycemic : Cinnamaldehyde
  • Hypoglycemic : Cinnamaldehyde
  • Hypolipidemic : Cinnamaldehyde
47
Maralhas A, Monteiro A, Martins C, Kranendonk M, Laires A, Rueff J, Rodrigues AS.(2006). Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol.. Mutagenesis. 21(3):199-204. DOI: 10.1093/mutage/gel017
  • Genotoxicity : Eugenol
48
Sivakumar J.T. Gowder, H. Devaraj(2006). Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney. Basic & clinical pharmacology & toxicology. 99(5):379-382. DOI: 10.1111/j.1742-7843.2006.pto_560.x
  • Antioxidant : Cinnamaldehyde
49
Shaik Mahaboob Ali, Aleem A Khan, Irshad Ahmed, M Musaddiq, Khaja S Ahmed, H Polasa, L Venkateswar Rao, Chittoor M Habibullah, Leonardo A Sechi, Niyaz Ahmed(2005). Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Annals of Clinical Microbiology and Antimicrobials. 4(20). DOI: 10.1186/1476-0711-4-20
  • Antibacterial : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
50
Usta J, Kreydiyyeh S, Barnabe P, Bou-Moughlabay Y, Nakkash-Chmaisse H(2003). Comparative study on the effect of cinnamon and clove extracts and their main components on different types of ATPases.. Human & experimental toxicology. 22(7):355-62. DOI: 10.1191/0960327103ht379oa
  • ATPase-Inhibitor : Cinnamaldehyde
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