SpiceCom: A database of phytochemicals in major spices

Black Pepper

Overview
Compounds
Activities
References
Crop: Black Pepper
Total No. of activities: 36
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1
Aroonsri Priprem, Pennapa Chonpathompikunlert, Saengrawee Sutthiparinyanont, Jintanaporn Wattanathorn , Jintanaporn Wattanathorn(2011). Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes. Advances in Bioscience and Biotechnology. 2:108-116 . DOI: 10.4236/abb.2011.22017
  • Antidepressant : Piperine
2
B.-S.Park, D.-J.Son, Y.-H.Park, T.W.Kim, S.-E.Lee(2007). Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.. Phytomedicine. 14(12):853-855. DOI: 10.1016/j.phymed.2007.06.011
  • Antiplatelet : Piperlongumine
3
Bang JS, Oh DH, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS.(2009). Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis research & therapy. 11(2):R49. DOI: 10.1186/ar2662
  • Antiarthritic : Piperine
  • Antiinflammatory : Piperine
  • Antinociceptive : Piperine
4
Bukhari IA, Pivac N, Alhumayyd MS, Mahesar AL, Gilani AH(2013). The analgesic and anticonvulsant effects of piperine in mice. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 64(6):789-94. DOI: NoDOI2
  • Analgesic : Piperine
  • Anticonvulsant : Piperine
5
Dogra RK, Khanna S, Shanker R(2004). Immunotoxicological effects of piperine in mice. Toxicology. 196(3):229-236. DOI: 10.1016/j.tox.2003.10.006
  • Immunosuppressant : Piperine
  • immunotoxic : Piperine
6
Dutta M, Ghosh AK, Mishra P, Jain G, Rangari V, Chattopadhyay A, Das T, Bhowmick D, Bandyopadhyay D.(2014). Protective effects of piperine against copper-ascorbate induced toxic injury to goat cardiac mitochondria in vitro.. Food & function. 5(9):2252-67. DOI: 10.1039/c4fo00355a
  • Antioxidant : Piperine
7
E.S Sunila, G Kuttan(2004). Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. Journal of Ethnopharmacology. 90(2-3):Journal of Ethnophar. DOI: 10.1016/j.jep.2003.10.016
  • Antitumor : Piperine
  • Immunomodulator : Piperine
8
Ee GC, Lim CM, Rahmani M, Shaari K, Bong CF(2010). Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum. Molecules. 15(4):2398-404. DOI: 10.3390/molecules15042398
  • Cytotoxic : Pellitorine
9
Evan Prince Sabina, Annie Deborah Harris Souriyan, Deborah Jackline, Mahaboob Khan Rasool(2010). Piperine, an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice. Asian Pacific Journal of Tropical Medicine. 3(12):971-976. DOI: 10.1016/S1995-7645(11)60011-4
  • Hepatoprotective : Piperine
10
Ferreira C., Soares D. C., Barreto-Junior C. B., et al.(2011). Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis. Phytochemistry. Phytochemistry. 72(17):2155-2164. DOI: 10.1016/j.phytochem.2011.08.006
  • Leishmanicidal : Piperine
11
Hirata N, Tokunaga M, Naruto S, Iinuma M, Matsuda H(2007). Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf. Biological & pharmaceutical bulletin. 30(12):2402-5. DOI: 10.1248/bpb.30.2402
  • 5-Alpha-Reductase-Inhibitor : (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin
  • 5-Alpha-Reductase-Inhibitor : (-)-cubebin
  • 5-Alpha-Reductase-Inhibitor : Piperine
  • Melanogenic : (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin
12
Hwang KS, Kim YK, Park KW, Kim YT.(2017). Piperolein B and piperchabamide D isolated from black pepper (Piper nigrum L.) as larvicidal compounds against the diamondback moth (Plutella xylostella).. Pest management science. 73(8):1564-1567. DOI: 10.1002/ps.4580
  • Insecticide : Piperolein-b
  • Larvicidal : Piperolein-b
13
Iqbal G, Iqbal A, Mahboob A, Farhat SM, Ahmed T.(2016). Memory Enhancing Effect of Black Pepper in the AlCl3 Induced Neurotoxicity Mouse Model is Mediated Through Its Active Component Chavicine.. Current pharmaceutical biotechnology. 17(11):962-73. DOI: 10.2174/1389201017666160709202124
  • Neurotoxic : Chavicine
14
Lai LH, Fu QH, Liu Y, Jiang K, Guo QM, Chen QY, Yan B, Wang QQ, Shen JG.(2012). Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model.. Acta pharmacologica Sinica. 33(4):523-30. DOI: 10.1038/aps.2011.209
  • Antitumor : Piperine
  • Antitumor : Piperine
15
Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW.(2007). Antidepressant-like effects of piperine and its derivative, antiepilepsirine. Journal of Asian natural products research. 9(3-5):421-30. DOI: 10.1080/10286020500384302
  • Antidepressant : Piperine
16
Matsuda H, Kawaguchi Y, Yamazaki M, Hirata N, Naruto S, Asanuma Y, Kaihatsu T, Kubo M(2004). Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents.. Biological and Pharmaceutical Bulletin. 27(10):1611-6. DOI: 10.1248/bpb.27.1611
  • Melanogenic : (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin
  • Melanogenic : Cubenene
17
Meriga B, Parim B1, Chunduri VR, Naik RR, Nemani H, Suresh P, Ganapathy S, Sathibabu Uddandrao VV(2017). Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats . Nutrition & metabolism. 14. DOI: 10.1186/s12986-017-0232-0
  • Antiobesity : Heliotropin
18
Michael Samuel, Shüné V. Oliver, Maureen Coetzee and Basil D. Brooke(2016). The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes. Parasites & vectors. 9:238. DOI: 10.1186/s13071-016-1521-6
  • Insecticide : Piperine
19
Minh Truong Do, Hyung Gyun Kim, Jae Ho Choi, Tilak hanal, Bong Hwan Park, Thu PhuongTran, Tae Cheon Jeong, Hye Gwang Jeong(2013). Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells. Food Chemistry. 141(3):2591-2599. DOI: 10.1016/j.foodchem.2013.04.125
  • Antitumor : Piperine
20
Mujumdar AM, Dhuley JN, Deshmukh VK, Raman PH, Naik SR(1990). Anti-inflammatory activity of piperine . Japanese journal of medical science & biology. 43(3):95-100. DOI: 10.7883/yoken1952.43.95
  • Antiinflammatory : Piperine
21
Paarakh PM, Sreeram DC, D SS, Ganapathy SP (2015). In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. . In silico pharmacology. 3(1):9. DOI: 10.1186/s40203-015-0013-2
  • Cytotoxic : Piperine
22
Park IK(2012). Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti.. Natural product research. 26(22):2129-31. DOI: 10.1080/14786419.2011.628178
  • Insecticide : Guineensine
  • Insecticide : Pellitorine
  • Insecticide : Pipercide
  • Insecticide : Retrofractamide-a
23
Park IK, Lee SG, Shin SC, Park JD, Ahn YJ(2002). Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species.. Journal of agricultural and food chemistry. 50(7):1866-70. DOI: 10.1021/jf011457a
  • Larvicidal : Guineensine
  • Larvicidal : Pellitorine
  • Larvicidal : Pipercide
  • Larvicidal : Piperine
  • Larvicidal : Retrofractamide-a
24
Pennapa Chonpathompikunlert, Jintanaporn Wattanathorn, Supaporn Muchimapur(2010). Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease. Food and Chemical Toxicology. 48(3):798-802. DOI: 10.1016/j.fct.2009.12.009
  • Neuroprotective : Piperine
  • Neurotrophic : Piperine
25
Pongkorpsakol P, Wongkrasant P, Kumpun S, Chatsudthipong V, Muanprasat C(2015). Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppers. Pharmacological Research. 100:271-280. DOI: 10.1016/j.phrs.2015.08.012
  • Antidiarrheal : Piperine
  • Antisecretory : Piperine
26
S.Venkat Reddy, Pullela V.Srinivas, B.Praveen, K.Hara Kishore, B.China Raju, U.Suryanarayana Murthy, J.Madhusudana Rao(2004). Antibacterial constituents from the berries of Piper nigrum. Phytomedicine. 11(7-8):697-700. DOI: 10.1016/j.phymed.2003.04.004
  • Antibacterial : Pellitorine
27
Selvendiran K, Singh JP, Krishnan KB, Sakthisekaran D(2003). Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia. 74(2-Jan):109-115. DOI: 10.1016/S0367-326X(02)00304-0
  • Antioxidant : Piperine
  • Cytoprotective : Piperine
28
Shrivastava P, Vaibhav K, Tabassum R, Khan A, Ishrat T, Khan MM, Ahmad A, Islam F, Safhi MM, Islam F(2013). Anti-apoptotic and Anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's Rat model. The Journal of Nutritional Biochemistry. 24(4):680-687. DOI: 10.1016/j.jnutbio.2012.03.018
  • Antiapoptotic : Piperine
  • Antiinflammatory : Piperine
  • Neuroprotective : Piperine
29
Sriwiriyajan S, Sukpondma Y, Srisawat T, Madla S, Graidist P.(2017). (-)-Kusunokinin and piperloguminine from Piper nigrum: An alternative option to treat breast cancer.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 92:732-743. DOI: 10.1016/j.biopha.2017.05.130
  • Anticancer : Piperlongumine
30
Tasleem F, Azhar I, Ali SN2, Perveen S, Mahmood ZA(2014). Analgesic and anti-inflammatory activities of Piper nigrum L. Asian Pacific Journal of Tropical Medicine. 7(1):S461-S468. DOI: 10.1016/S1995-7645(14)60275-3
  • Analgesic : Piperine
  • Antiinflammatory : Piperine
31
Vijayakumar RS, Nalini N(2006). Piperine, an Active Principle from Piper Nigrum, Modulates Hormonal and Apolipoprotein Profiles in Hyperlipidemic Rats. Journal of Basic and Clinical Physiology and Pharmacology. 17(2):71-86. DOI: 10.1515/JBCPP.2006.17.2.71
  • Thyrogenic : Piperine
32
Vijayakumar RS, Surya D, Nalini N.(2004). Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress.. Redox report : communications in free radical research. 9(2):105-10. DOI: 10.1179/135100004225004742
  • Antioxidant : Piperine
33
Vinturelle R,, Mattos C, Meloni J, Nogueira J, Nunes MJ, Vaz IS Jr, Rocha L, Lione V, Castro HC, Chagas EFD(2017). In Vitro Evaluation of Essential Oils Derived from Piper nigrum (Piperaceae) and Citrus limonum (Rutaceae) against the Tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Biochemistry Research International. 2017. DOI: 10.1155/2017/5342947
  • Antiinflammatory : Caryophylline
  • Leishmanicidal : Piperine
34
Wongpa S, Himakoun L, Soontornchai S, Temcharoen P(2007). Antimutagenic Effects of Piperine on Cyclophosphamide-induced Chromosome Aberrations in Rat Bone Marrow Cel. Asian Pacific journal of cancer prevention: APJCP. 8(4):623-627. DOI: NoDOI4
  • Antimutagenic : Piperine
35
Xiaozhou Ying, Xiaowei Chen, Shaowen Chen, Yue Shena, Lei Peng, Hua zi Xu(2013). Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte. International Immunopharmacology. 17(2):293-299. DOI: 10.1016/j.intimp.2013.06.025
  • Antiinflammatory : Piperine
36
Yaffe PB, Power Coombs MR, Doucette CD, Walsh M, Hoskin DW(2015). Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress.. Molecular carcinogenesis. 54(10):1070-85. DOI: 10.1002/mc.22176
  • Anti-colon cancer : Piperine
  • Antiproliferative : Piperine
  • Apoptosis inducer : Piperine
37
Yanbei Tu, Yujiao Zhong, Hongjian Du, Wei Luo, Yaya Wen, Qin Li, Chao Zhu, Yanfang Li(2016). Anticholinesterases and antioxidant alkamides from Piper nigrum fruits. Natural Product Research. 30(17):1945-9. DOI: 10.1080/14786419.2015.1089243
  • AChE-Inhibitor : Piperettine
  • AChE-Inhibitor : Piperine
  • BChE-inhibitor : Feruperine
  • BChE-inhibitor : Piperettine
  • BChE-inhibitor : Piperine
38
Zied Zarai, Emna Boujelbene, Nadia Ben Salem, Youssef Gargouri, Adel Sayari(2013). Antioxidant and antimicrobial activities of various solvent extracts, piperine and piperic acid from Piper nigrum. LWT - Food Science and Technology. 50(2):634-641. DOI: 10.1016/j.lwt.2012.07.036
  • Antibacterial : Piperine
  • Antioxidant : Piperine
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