SpiceCom: A database of phytochemicals in major spices

Cinnamon

Overview
Compounds
Activities
References
Crop: Cinnamon
Total No. of activities: 46
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1
Yoo W, Yoo D, Hong E, Jung E, Go Y, Singh SVB, Khang G, Lee D3(2018). Acid-activatable oxidative stress-inducing polysaccharide nanoparticles for anticancer therapy.. Journal of controlled release : official journal of the Controlled Release Society. 269:235-244. DOI: 10.1016/j.jconrel.2017.11.023
  • Anticancer : Cinnamaldehyde
2
Yue Wang, Yi Zhang, Yan-qin Shi, Xian-hua Pan, Yan-hua Lu, Ping Cao(2018). Antibacterial effects of cinnamon (Cinnamomum zeylanicum) bark essential oil on Porphyromonas gingivalis. Microbial Pathogenesis. 116:26-32. DOI: 10.1016/j.micpath.2018.01.009
  • Antibacterial : Cinnamaldehyde
  • Antibiofilm : Cinnamaldehyde
  • Antimicrobial : Cinnamaldehyde
3
Hosni AA, Abdel-Moneim AA, Abdel-Reheim ES, Mohamed SM, Helmy H(2017). Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARγ, proinflammatory cytokines and oxidative stress.. Biomedicine & Pharmacotherapy. 88:52-60. DOI: 10.1016/j.biopha.2017.01.054
  • Hypoglycemic : Cinnamaldehyde
4
Monteiro IN, Monteiro ODS, Costa-Junior LM, da Silva Lima A, Andrade EHA, Maia JGS, Mouchrek Filho VE.(2017). Chemical composition and acaricide activity of an essential oil from a rare chemotype of Cinnamomum verum Presl on Rhipicephalus microplus (Acari: Ixodidae).. Vet Parasitol.. 238:00:00(-):54-57. DOI: 10.1016/j.vetpar.2017.03.016
  • Acaricide : Benzyl-benzoate
  • Acaricide : Eugenol
5
Sharma UK, Sharma AK, Gupta A, Kumar R, Pandey A, Pandey AK(2017). Pharmacological activities of cinnamaldehyde and eugenol: antioxidant, cytotoxic and anti-leishmanial studies.. Cellular and molecular biology (Noisy-le-Grand, France). 63(6):73-78. DOI: 10.14715/cmb/2017.63.6.15
  • Antileishmanial : Cinnamaldehyde
  • Antileishmanial : Eugenol
  • Antioxidant : Cinnamaldehyde
  • Antioxidant : Eugenol
  • Cytotoxic : Cinnamaldehyde
  • Cytotoxic : Eugenol
6
Deletre E, Chandre F, Barkman B, Menut C, Martin T(2016). Naturally occurring bioactive compounds from four repellent essential oils against Bemisia tabaci whiteflies. Pest management science. 72(1):179-89. DOI: 10.1002/ps.3987
  • Repellent : Cinnamaldehyde
7
Wong HY, Tsai KD1, Liu YH, Yang SM1,, Chen TW, Cherng J, Chou KS, Chang CM, Yao BT, Cherng JM(2016). Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytotherapy research : PTR. 30(2):331-40. DOI: 10.1002/ptr.5536
  • Anticancer : 2-methoxycinnamaldehyde
  • Antiproliferative : 2-methoxycinnamaldehyde
  • Chemopreventive : 2-methoxycinnamaldehyde
  • NF-kB-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-I-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-II-Inhibitor : 2-methoxycinnamaldehyde
8
Mendes SJ, Sousa FI, Pereira DM, Ferro TA, Pereira IC, Silva BL, Pinheiro AJ, Mouchrek AQ, Monteiro-Neto V, Costa SK, Nascimento JL, Grisotto MA, da Costa R, Fernandes ES(2016). Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms. International Immunopharmacology. 34:60-70. DOI: 10.1016/j.intimp.2016.02.012
  • Immunomodulatory : Cinnamaldehyde
9
AkshayJawalea, Ashok Kumar Datusaliaa, Mahendra Bishnoi, Shyam S.Sharma(2016). Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde. Phytomedicine. 23(9):923-930. DOI: 10.1016/j.phymed.2016.04.008
  • AChE-Inhibitor : Cinnamaldehyde
10
Imad Hadi Hameed, Huda Jasim Altameme, Ghaidaa Jihadi Mohammed(2016). Evaluation of Antifungal and Antibacterial Activity and Analysis of Bioactive Phytochemical Compounds of Cinnamomum Zeylanicum (Cinnamon Bark) using Gas Chromatography-Mass Spectrometry. Oriental Journal of Chemistry. 32(4):1769-1788. DOI: 10.13005/ojc/320406
  • Antimicrobial : Cinnamaldehyde
11
Connell BJ, Chang SY, Prakash E, Yousfi R, Mohan V, Posch W, Wilflingseder D, Moog C, Kodama EN7, Clayette P, Lortat-Jacob H(2016). A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.. PloS one. 11(10). DOI: 10.1371/journal.pone.0165386
  • AntiHIV : Ind02-trimer
12
Perng DS, Tsai YH, Cherng J, Wang JS, Chou KS, Shih CW, Cherng JM(2016). Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. Drug Design, Development and Therapy. 10:141–153. DOI: 10.2147/DDDT.S93599
  • Anticancer : 2-methoxycinnamaldehyde
  • NF-kB-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-I-Inhibitor : 2-methoxycinnamaldehyde
  • Topoisomerase-II-Inhibitor : 2-methoxycinnamaldehyde
13
Kuen-daw Tsai, Yi-Heng Liu, Ta-Wei Chen, Shu-Mei Yang, Ho-Yiu Wong, Jonathan Cherng, Kuo-Shen Chou, Jaw-Ming Cherng(2016). Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells. Nutrients. 8(6). DOI: 10.3390/nu8060318
  • Anticancer : Cuminaldehyde
  • Antiproliferative : Cuminaldehyde
  • Chemopreventive : Cuminaldehyde
14
Hagenlocher Y, Kiessling K, Schäffer M, Bischoff SC, Lorentz A(2015). Cinnamaldehyde is the main mediator of cinnamon extract in mast cell inhibition.. European journal of nutrition. 54(8):1297-309. DOI: 10.1007/s00394-014-0810-0
  • Antiallergic : Cinnamaldehyde
15
Yong-Guy Kim, Jin-Hyung Lee, Soon-Il Kim, Kwang-Hyun Baek, Jintae Lee(2015). Cinnamon bark oil and its components inhibit biofilm formation and toxin production. International Journal of Food Microbiology. 195:30-39. DOI: 10.1016/j.ijfoodmicro.2014.11.028
  • Antibiofilm : Cinnamaldehyde
  • Antibiofilm : Eugenol
  • Antihemolytic : Cinnamaldehyde
  • Antihemolytic : Eugenol
16
Williams AR, Ramsay A, Hansen TV, Ropiak HM, Mejer H, Nejsum P, Mueller-Harvey I, Thamsborg SM(2015). Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum). Scientific reports. 5:14791. DOI: 10.1038/srep14791
  • Anthelmintic : Cinnamaldehyde
17
Gunawardena D1, Karunaweera N, Lee S, van Der Kooy F, Harman DG, Raju R, Bennett L, Gyengesi E, Sucher NJ, Münch G(2015). Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - Identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds. Food & Function. 6(3). DOI: 10.1039/c4fo00680a
  • Antiinflammatory : 2-methoxycinnamaldehyde
  • Antiinflammatory : Cinnamaldehyde
18
Homa M, Fekete IP, Böszörményi A, Singh YR, Selvam KP, Shobana CS, Manikandan P6, Kredics L, Vágvölgyi C, Galgóczy L(2015). Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates. Planta Medica. 81(14):1277-84. DOI: 10.1055/s-0035-1546272
  • Antifungal : Cinnamaldehyde
19
Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, Zhang DD, Wondrak GT(2015). Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prevention Research. 8(5):444-54. DOI: 10.1158/1940-6207.CAPR-14-0359
  • Anti-colon cancer : Cinnamaldehyde
  • Chemopreventive : Cinnamaldehyde
  • Nrf2 inducer : Cinnamaldehyde
20
Deletre E, Chandre F, Williams L, Duménil C, Menut C, Martin T(2015). Electrophysiological and behavioral characterization of bioactive compounds of the Thymus vulgaris, Cymbopogon winterianus, Cuminum cyminum and Cinnamomum zeylanicum essential oils against Anopheles gambiae and prospects for their use as bednet treatments. Parasites & vectors. 8:316. DOI: 10.1186/s13071-015-0934-y
  • Repellent : Cinnamaldehyde
21
Kot B, Wicha J, Piechota M, Wolska K, Gruzewska A(2015). Antibiofilm activity of trans-cinnamaldehyde, p-coumaric, and ferulic acids on uropathogenic Escherichia coli.. Turkish journal of medical sciences. 45(4):919-24. DOI: 10.3906/sag-1406-112
  • Antibiofilm : Cinnamaldehyde
22
Muthenna P, Raghu G1, Kumar PA, Surekha MV, Reddy GB(2014). Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chemico-Biological Interactions. 222:68-76. DOI: 10.1016/j.cbi.2014.08.013
  • AntiAGE : Procyanidin b2
23
Fraňková A1, Marounek M, Mozrová V, Weber J, Klouček P, Lukešová D(2014). Antibacterial activities of plant-derived compounds and essential oils toward Cronobacter sakazakii and Cronobacter malonaticus.. Foodborne Pathogens and Disease. 11(10):795-7. DOI: 10.1089/fpd.2014.1737
  • Antibacterial : Cinnamaldehyde
24
Tina Sartorius, Andreas Peter, Nadja Schulz, Andrea Drescher, Ina Bergheim, Jürgen Machann, Fritz Schick, Dorothea Siegel-Axel, Annette Schürmann, Cora Weigert, Hans-Ulrich Häring, Anita M. Hennige(2014). Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity. PLOS ONE. 9(3). DOI: 10.1371/journal.pone.0092358
  • Antidiabetic : Eugenol
25
Muthenna P, Raghu G, Akileshwari C, Sinha SN, Suryanarayana P, Reddy GB(2013). Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: Delay of diabetic cataract in rats. IUBMB life. 65(11):941-950. DOI: 10.1002/iub.1214
  • AntiAGE : Procyanidin b2
  • Antiglycating : Procyanidin b2
26
El-Sayed el-SM, Abd El-Raouf OM, Fawzy HM, Manie MF(2013). Comparative study of the possible protective effects of cinnamic acid and cinnamaldehyde on cisplatin-induced nephrotoxicity in rats.. Journal of biochemical and molecular toxicology. 27(12):508-514. DOI: 10.1002/jbt.21515
  • Nephroprotective : Cinnamaldehyde
  • Nephroprotective : Cinnamic-acid
27
Abhinav Upadhyay, Indu Upadhyaya, Anup Kollanoor-Johny, Kumar Venkitanarayanan(2013). Antibiofilm effect of plant derived antimicrobials on Listeria monocytogenes. Food Microbiology. 36(1):79-89. DOI: 10.1016/j.fm.2013.04.010
  • Antibiofilm : Cinnamaldehyde
28
Ho SC, Chang KS, Chang PW(2013). Inhibition of neuroinflammation by cinnamon and its main components. Food Chemistry. 138(4):2275-2282. DOI: 10.1016/j.foodchem.2012.12.020
  • Anti-neuroinflammatory : Cinnamaldehyde
29
Naveed R, Hussain I, Tawab A, Tariq M, Rahman M, Hameed S, Mahmood MS, Siddique AB, Iqbal M(2013). Antimicrobial activity of the bioactive components of essential oils from Pakistani spices against Salmonella and other multi-drug resistant bacteria. BMC Complementary and Alternative Medicine. 13(265). DOI: 10.1186/1472-6882-13-265
  • Antimicrobial : Cinnamaldehyde
30
Takasao N, Tsuji-Naito K, Ishikura S, Tamura A, Akagawa M(2012). Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts.. Journal of agricultural and food chemistry. 60(5):1193-200. DOI: 10.1021/jf2043357
  • Antiaging : Cinnamaldehyde
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