SpiceCom

The following plants show the Antiacetylcholinesterase activity due to the presence of phytochemicals.

Ginger

Ginger is one of the most commonly consumed dietary condiments in the world (Surh et al. 1999). The oleoresin (i.e., oily resin) from the rhizomes (i.e., roots) of ginger contains many bioactive components, such as [6]-gingerol which is the primary pungent ingredient that is believed to ...

Turmeric

Turmeric is a rhizomatous herbaceous perennial flowering plant of the ginger family, Zingiberaceae. It is native to the Indian subcontinent and Southeast Asia, and requires temperatures between 20 and 30 °C (68 and 86 °F) and a considerable amount of annual rainfall to thrive. Plants are gat...

The following compounds have found to show the Antiacetylcholinesterase.

CURCUMIN
IUPAC Name	(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Molecular formula	C₂₁H₂₀O₆ ..more

GINGERENONE-A
IUPAC Name	(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one
Molecular formula	C₂₁H₂₄O₅ ..more

Akinyemi AJ, Oboh G, Ogunsuyi O, Abolaji AO, Udofia A(2018). Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model. Metabolic Brain Disease. 33(2):369-375. DOI: 10.1007/s11011-017-0100-7
Compounds: Curcumin

Akinyemi AJ, Oboh G, Fadaka AO, Olatunji BP, Akomolafe S(2017). Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. NeuroToxicology. 62:75-79. DOI: 10.1016/j.neuro.2017.05.004
Compounds: Curcumin

Cuya T, Baptista L, Celmar Costa França T(2017). A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease.. Journal of biomolecular structure & dynamics. :13-Jan. DOI: 10.1080/07391102.2017.1401004
Compounds: Gingerenone-a

SpiceCom: A database of phytochemicals in major spices

Antiacetylcholinesterase Activity