SpiceCom

The following plants show the Antialzheimer activity due to the presence of phytochemicals.

Ginger

Ginger is one of the most commonly consumed dietary condiments in the world (Surh et al. 1999). The oleoresin (i.e., oily resin) from the rhizomes (i.e., roots) of ginger contains many bioactive components, such as [6]-gingerol which is the primary pungent ingredient that is believed to ...

Turmeric

Turmeric is a rhizomatous herbaceous perennial flowering plant of the ginger family, Zingiberaceae. It is native to the Indian subcontinent and Southeast Asia, and requires temperatures between 20 and 30 °C (68 and 86 °F) and a considerable amount of annual rainfall to thrive. Plants are gat...

The following compounds have found to show the Antialzheimer.

6-GINGEROL
IUPAC Name	(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
Molecular formula	C₁₇H₂₆O₄ ..more

6-SHOGAOL
IUPAC Name	(E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one
Molecular formula	C₁₇H₂₄O₃ ..more

CURCUMIN
IUPAC Name	(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Molecular formula	C₂₁H₂₀O₆ ..more

Zeng GF, Zong SH, Zhang ZY, Fu SW, Li KK, Fang Y, Lu L, Xiao DQ(2015). The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells. Rejuvenation Research. 18(5):413-21. DOI: 10.1089/rej.2014.1657
Compounds: 6-gingerol

Lee C, Park GH, Kim CY, Jang JH(2011). [6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system. Food and Chemical Toxicology. 49(6):1261-1269. DOI: 10.1016/j.fct.2011.03.005
Compounds: 6-gingerol

Yan FS, Sun JL, Xie WH, Shen L, Ji HF(2017). Neuroprotective Effects and Mechanisms of Curcumin-Cu(II) and -Zn(II) Complexes Systems and Their Pharmacological Implications. Nutrients. 10(1). DOI: 10.3390/nu10010028
Compounds: Curcumin

Na JY, Song K, Lee JW, Kim S, Kwon J(2016). 6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer's disease via CysLT1R-mediated inhibition of cathepsin B. Biochemical and Biophysical Research Communications. 477(1):96-102. DOI: 10.1016/j.bbrc.2016.06.026
Compounds: 6-shogaol

Moon M, Kim HG, Choi JG, Oh H, Lee PK, Ha SK, Kim SY, Park Y, Huh Y, Oh MS(2014). 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. Biochemical and Biophysical Research Communications. 449(1):13-Aug. DOI: 10.1016/j.bbrc.2014.04.121
Compounds: 6-shogaol

SpiceCom: A database of phytochemicals in major spices

Antialzheimer Activity