5-Alpha-Reductase-Inhibitor Activity
The following plants show the 5-Alpha-Reductase-Inhibitor activity due to the presence of phytochemicals.
Black pepper
Black pepper (Piper nigrum) is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning, known as a peppercorn. When fresh and fully mature, it is about 5 mm (0.20 in) in diameter and dark red, and contains a single seed, like all ...
The following compounds have found to show the 5-Alpha-Reductase-Inhibitor.
1 
| (-)-3,4-DIMETHOXY-3,4-DESMETHYLENEDIOXYCUBEBIN | |
| IUPAC Name | (3R,4R)-3-(1,3-benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]oxolan-2-ol |
|---|---|
| Molecular formula | C21H24O6 ..more |
2 
| (-)-CUBEBIN | |
| IUPAC Name | (2S,3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)oxolan-2-ol |
|---|---|
| Molecular formula | C20H20O6 ..more |
3 
| PIPERINE | |
| IUPAC Name | (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one |
|---|---|
| Molecular formula | C17H19NO3 ..more |
Hirata N, Tokunaga M, Naruto S, Iinuma M, Matsuda H(2007). Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf. Biological & pharmaceutical bulletin. 30(12):2402-5. DOI: 10.1248/bpb.30.2402
Compounds: (-)-cubebin, Piperine, (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin
Compounds: (-)-cubebin, Piperine, (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin